MYOCARDIAL REMODELING IN OBESE YOUNG WOMEN

Abstract

Objective. The aim of the study was to investigate left ventricular (LV) structural changes in overweight and obese young women with arterial hypertension (AH).Design and methods. In the study, according to inclusion criteria, 108 young women of 18-45 years old were included. Three groups were identified: the women with obesity without arterial hypertension, the women with obesity and 1-st degree of arterial hypertension, the women with obesity and 2-nd degree of arterial hypertension. All patients underwent anthropometry (height and weight) with calculation of body mass index (BMI), echocardiography was performed according to a standard procedure with calculation of LV structural indexes. The LV geometry phenotypes were determined.Results. Echocardiography LV dimensions (posterior wall thickness, interventricular septal thickness, diastolic and systolic LV diameter), as well as LVM and LVMI were higher in obese women compared to control group. LV hypertrophy (LVH) developed in 61,9% obese patients without AH and in 76,4% and 78,1% patients with obesity and AH. Normal LV geometry was found in 23,8% patients with obesity, concentric remodeling - in 14,3% cases, 35,7% patients had concentric LVH, and 26,2% - eccentric LVH. In obese patients with 1-st degree of AH the distribution of various types of LV remodeling was as follows: 17,6% / 6% / 52,9% / 23,5%, respectively, and in obese patients with 2-nd degree of AH - 12,5% / 9,4% / 53,1% / 25%, respectively.Conclusions. Young age overweight and obesity are risk factors for LVH and the development of various LV geometry phenotypes. Markers of myocardial remodeling is an affordable way of early cardiovascular risk stratification in overweight and obese young women.