POSSIBILITIES OF IMMUNOLOGICAL ELI-TEST IN THE DIFFERENTIAL DIAGNOSIS OF PULMONARY TUBERCULOSIS AND SARCOIDOSIS

Abstract

The article presents the results of the screening immunological ELI-test to identify levels of autoantibodies (AAB) to 24 types of tissues of organs and systems of the body in patients with tuberculosis (TL) (53 people) and sarcoidosis (SL) (24 patients) of the lungs. A large mosaic of target organs and systems at TL and SL was revealed: in the first case, AAB was determined in 10 samples (in 6 - in high concentrations), at SL - in 15 (high concentration - in one case) above the norm. Mean values of AAB levels at TL were less than in healthy people, were determined with the value «-» (LuM-02 - 33,1±5,4%; LuS-06 - 15,0±2,3%), and at SL the same average indicators were higher than in healthy people, recorded with the sign «+», amounted to +3,5±1,8% and +4,3±2,5%, respectively, were significantly higher than their values at TL (p<0,05). It can be assumed that in TL there is a mechanism to block the production of immunocompetent cells AAB to antigens of damaged lung tissues, and in SL test results indicate the autoimmune nature of lung tissue lesions.