DERINAT INFLUENCE ON EFFICIENCY OF COMPLEX TREATMENT OF PULMONARY TUBERCULOSIS

Abstract

The study was conducted to evaluate the effectiveness of the use of the deoxyribonucleate sodium immunomodulator - «Derinat» in the complex therapy of 60 newly diagnosed patients with infiltrative and disseminated pulmonary tuberculosis. All of them received specific chemotherapy for pulmonary tuberculosis. Patients were divided into 2 groups - the main one - 30 patients, who were prescribed «Derinat» intra-muscular for 5 ml of solution, 5 injections per course and inhalation (spray) once a day, the course of 25-30 procedures. In the comparison group, there were 30 patients, whom «Derinat» was not assigned. The use of «Derinat» in the complex treatment of patients with advanced forms of pulmonary tuberculosis allows to achieve a cessation of bacterial release by 6th month of treatment in 66.7%, in the comparison group - only in 16% of patients (p = 0.003). There was an increase in the number of lymphocytes by 4th month of treatment (p = 0.04). In the main group, resorption of infiltration was achieved in a larger number of patients than in the control group (p = 0.012).