FEATURES OF LIPID AND CARBOHYDRATE METABOLISM DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C DEPENDING ON THE GENOTYPE OF THE VIRUS

Abstract

The study aims to determine the effect of metabolic changes in patients with chronic HCV depending on the genotype of the virus and the stage of fibrosis on the course of the disease.The work was based on the analysis of the cohort examination of 287 patients with chronic hepatitis C. Fatty liver dystrophyfrom the 1st to the 3rd degree, according to puncture biopsy, was 61.0%. Chronic hepatitis C and non-alcoholic fatty liver disease are accompanied by significant violations of lipid and carbohydrate metabolism, a higher body mass index and severe cholestatic syndrome. Accordingly, the average value of fibrosis and histological activity index were significantly higher in patients with chronic hepatitis C with a burdened comorbid background in the form of fatty liver dystrophy, regardless of the genotype of the virus.Conclusion: Patients with chronic hepatitis C with an unfavorable premorbid background need a personalized approach, advanced laboratory monitoring and an interdisciplinary approach to the risk of complications.