SEARCH FOR ASSOCIATION OF CLINICAL AND ANAMNESTIC DATA IN CHILDREN WITH BRONCHIAL ASTHMA WITH RS 28364072 (T2206C) POLYMORPHISM OF FCER2 GENE

The aim of this study was to study the distribution of alleles and genotypes of rs 28364072 (T2206C) polymorphic locus of gene Fc fragment of IgE receptor II (FCER2) in children with asthma.Material and methods. The study included 92 patients with bronchial asthma from Bashkortostan, Russia. The control group consisted of 99 healthy students of Bashkir State Medical University (Ufa, Russia), who had no chronic respiratory diseases at thetime of the study. Genotyping was performed by real-time polymerase chain reaction.Results. During the study, no significant differences in the distribution of allele and genotype frequencies in patients with bronchial asthma and in the control group were established (p>0.05). The frequency of 2206*C allele of FCER2 gene was 26.08% in patients with bronchial asthma and 34.84% in the control group. No association of clinical and anamnestic data of children with bronchial asthma with alleles and genotypes of rs28364072 (T2206C) polymorphism of FCER2 gene was found.Conclusion. It is necessary to expand the sampling to increase its representativeness, as well as to continue the identification and inclusion of patients with different variants of the disease course and response to IGCs therapy.

бронхиальная астма, дети, полиморфный локус, ген Fc-фрагмента рецептора II IgE (FCER2), bronchial asthma, children, polymorphic locus, the gene for Fc fragment of IgE receptor II (FCER2)