FEATURES OF IMMUNOLOGICAL INDICATORS IN CHRONIC BACTERIAL PROSTITIS

Abstract

Hyperactivation of cytokines is a very characteristic symptom in prostatitis.Purpose of the study. The article assesses the content of cytokines in the ejaculate of men suffering from chronic bacterial prostatitis and concomitant infertility to determine their role as predictors of reproductive pathology.Material and methods. The survey included 82 men treated in clinics to restore reproductive function. The control group consisted of 29 patients of reproductive age. A significant increase in the content of IL-18 and IFN-γ was found. At the same time, the content of IL-1β, IL-7, SDF-1α, TGF-β decreased. The study of samples of patients with impaired reproductive function showed the presence of significant differences in comparison with samples of the group of fertile patients.Results. Violations in the regulation of TGF-β and IL-18 are the most prognostic indicators in inflammatory processes of the male genital tract in assessment of the reproductive system status.Conclusions. The results create the basis for the inclusion of cytokine analysis in clinical practice to evaluate the reproductivesystem, primarily in cases of disorders caused by inflammatory and immunopathological processes.