FEATURES OF PHARMACOLOGICAL SUPPORT IN THE EARLY POSTOPERATIVE PERIOD FOR PATIENTS AFTER RADICAL NEPHRECTOMY

Objective: to improve the results of radical nephrectomy by pharmacological correction of violations of adaptation reactivity of the organism, and the only kidney in the early postoperative period.Material and Methods: Two groups of 45 patients after nephrectomy were examined. Patients of one group received an additional course of synthetic adaptogen Selank within 14 days of the postoperative period.Results: nephrectomy is a powerful stress factor leading to an imbalance of nutrient stress amines, psycho-emotional and vegetative-vascular disorders accompanied by severe violation of the filtration capacity of a single kidney. Additional course of SelankМедицинский вестник Башкортостана. Том 15, № 1 (85), 20209within 14 days (as opposed to its single purpose) was significantly more effective and reliably led to the restoration of the adaptive capacity of the body (reduced plasma levels of adrenaline, histamine and increased plasma levels of serotonin; normalized psychoemotional and vegetative-vascular status of patients), which was accompanied by a less severe impaired renal filtration capacity of the only kidney.Conclusion: Selank demonstrated reliable anti-stress, adaptogenic, anxiolytic, vegetative stabilization and renal protection, that allows to recommend it for pharmacological correction of desadaptation stress and maintainance of the functions of a single kidney after nephrectomy.

нефрэктомия, адаптационная реактивность, дезадаптационный стресс, единственная почка, адаптогены, фармакотерапия, nephrectomy, adaptation reactivity, desadaptation stress, solitary kidney, adaptogens, pharmacotherapy