MINERAL DENSITY AND BONE METABOLISMIN ADULTS LIVING IN AN IODINE-DEFICIENT AREA

Abstract

The Republic of Bashkortostan belongs to the iodine-deficient regions. Iodine deficiency adversely affects the functional state of thyroid gland known to have pronounced effects on bone tissue metabolism. The available literature includes only few reports describing the state of bone tissue in adult population living in the iodine-deficient region.The present study shows the results of remodeling intensity and bone mineral density regarding the severity of iodine deficiency. Study methods included evaluation of thyroid gland volume, thyroid hormone analysis in plasma, investigation of bone mineral density of the axial and peripheral skeleton and bone remodeling intensity. The high prevalence of iodine deficiency was detected in 59.5% of393 examined residents in the Republic of Bashkortostan aged 24-44 (including 14.1% of severe degree and low median ioduria - 75.5 [50.4-122.3] ug/L). It was observed that uncompensated iodine deficiency is accompanied by decrease in mineral density and intensity of bone remodeling, dissociation of the remodeling balance with the prevalence of osteoresorption. The obtained data indicate the need for a screening study of bone strength in individuals with hypothyroidism for correction of bone mineral density.