ANALYSIS OF ASSOCIATIONS OF POLYMORPHISMS OF THE GLUCOCORTICOID RECEPTOR GENE (NR3C1) AND THE CORTICOTROPIN RELEASING HORMONE GENE (CRHR1) ON THE DEVELOPMENT AND COURSE OF BRONCHIAL ASTHMA
Abstract
Bronchial asthma is a severe, common and disabling multifactorial disease. It has been shown that about 50-60% of differences in sensitivity to asthma therapy in patients are determined by genetics. The aim of the investigation was to study the role of polymorphic variants of the glucocorticoid receptor gene ( NR3C1 ) and the corticotropin releasing hormone receptorgene ( CRHR1 ) in the development and course of asthma. DNA samples of 212 asthma patients and DNA samples of 252 control individuals aged 18-67 years, living in the Republic of Bashkortostan, were used as the study material. Genotyping was performed using PCR-RFLP analysis and real-time PCR methods. The associations of the rs1876828* CT genotype of the CRHR1 gene with asthma in general group of patients and the rs242941* AC genotype of the CRHR1 gene with asthma in men were established. The association of the rs1876828* T allele of the CRHR1 gene with an early age of manifestation of bronchial obstruction was defined. The associations of the rs41423247* CG genotype of the NR3C1 gene and the rs1876828* T allele of the CRHR1 gene with significant reductions in spirometric measures in women were revealed.
About the Authors
O. N. Savelieva
ФГБОУ ВО «Башкирский государственный университет», г. Уфа 2Институт биохимии и генетики УФИЦ РАН
Russian Federation
Russian Federation
A. S. Karunas
Институт биохимии и генетики УФИЦ РАН; ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; ФГБОУ ВО «Санкт-Петербургский государственный университет»
Russian Federation
Russian Federation
Yu. Yu. Fedorova
Институт биохимии и генетики УФИЦ РАН; ФГБОУ ВО «Санкт-Петербургский государственный университет»
Russian Federation
Russian Federation
L. A. Mukhtarova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
Sh. Z. Zagidullin
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
E. K. Khusnutdinova
Институт биохимии и генетики УФИЦ РАН; ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; ФГБОУ ВО «Санкт-Петербургский государственный университет»
Russian Federation
Russian Federation
Review
For citations:
Savelieva O.N., Karunas A.S., Fedorova Yu.Yu., Mukhtarova L.A., Zagidullin Sh.Z., Khusnutdinova E.K. ANALYSIS OF ASSOCIATIONS OF POLYMORPHISMS OF THE GLUCOCORTICOID RECEPTOR GENE (NR3C1) AND THE CORTICOTROPIN RELEASING HORMONE GENE (CRHR1) ON THE DEVELOPMENT AND COURSE OF BRONCHIAL ASTHMA. Bashkortostan Medical Journal. 2020;15(1):37-40. (In Russ.)
Views:
85
Email this article 
