ANALYSIS OF ANTIBACTERIAL THERAPY OF ELDERLY PATIENTS WITH SEPSIS ON THE BACKGROUND OF COMORBID PATHOLOGY

Sepsis and concomitant organ dysfunction are actual problems of modern health care. Any infection in the context of comorbidity becomes a fact that worsens the course of all concomitant diseases, which ultimately increases the risk of death. A significant increase in the number of patients at risk of developing sepsis in the next decade is expected due to the development of invasive medical technologies, the uncontrolled use of broad-spectrum antibiotics, and an increase in the number of microbes resistant to antibiotics. This article analyzes causative agents of community-acquired non-surgical sepsis in elderly patients with comorbid pathology. In order to more quickly identify the pathogen, the MALDI-TOF method was used. Septicemia was detected in 59% of cases of sepsis. Gram-negative microorganisms such as Klebssiella pneumonia and Acinetobacter baumannii played a dominant role in the development of sepsis. 91.3% of microorganisms were multiresistant. The most common antibacterial drugs that were administered empirically were protected aminopenicillins. Carpapenems and polymyxins prevailed when changing antibiotic therapy. Our findings confirm current trends and dictate the need to review the schemes of empirical and causal antibiotic therapy. In our study, the time of the change of antibacterial therapy did not affect mortality, this thesis contradicts the data of modern literature and requires clarification for further research.

нехирургический сепсис, метод MALDI-TOF, антибиотикорезистентность, non-surgical sepsis, MALDI-TOF method, antibiotic resistance