CLINICAL AND GENETIC CHARACTERISTICS OF SUICIDAL BEHAVIOR OF PATIENTS WITH SYNTHETIC CATHINONES ADDICTION

The article describes the phenomenon of suicidal behavior in people dependent on synthetic cathinones - drugs of a new generation of “designer” synthetic drugs. The purpose of the article is to assess the level of forms of suicidal behavior, to analyze the association of internal and external forms of suicidal behavior and anxiety, to identify genetic markers of suicidal behavior risk in people dependent on synthetic cathinones and healthy individuals.Results: a significant increase of the level of suicidal behavior was found in those dependent on synthetic cathinones comparedwith healthy individuals (p = 0.0063). Among those dependent on synthetic cathinones, 74 (41%) were among the healthy and 11 people (6.6%) who had external forms of suicidal behavior. Internal forms of suicidal behavior were determined in 111 (61%) patients, in the control group - 26 (15.6%). The presence of anxiety in a state of intoxication and prolonged abstinence dependent on synthetic cathinones increases the risk of suicide. Analysis of the data obtained showed a statistically significant association between the presence of anxiety, detected during clinical interviewing, in the structure of the syndrome of synthetic cathinones and suicidal attempts (p = 0.028; χ² = 4.772); the presence of anxiety in the period of prolonged abstinence (p = 0.002; χ² = 9.232). Our analysis of the frequency distribution of the genotypes and alleles of the polymorphic loci rs6313 of the HTR2A gene and rs6296 of the HTR1B gene did not reveal statistically significant differences between patients and healthy individuals. Data analysis revealed the presence of a statistically significant association of the frequencies of the polymorphic loci of the rs6313 *C/C genotype of the НТR2А gene with the internal form of suicidal behavior (χ² = 9,146; p = 0.01) in those dependent on synthetic cathinones.Conclusion:1. We have identified a significant increase of the level of suicidal behavior among those dependent on synthetic cathinones compared with healthy individuals.2. The presence of anxiety in a state of intoxication and prolonged abstinence in synthetic cathinones addicts increases the risk of suicide.3. We found that markers of an increased risk of an internal form of suicidal behavior in dependent on synthetic cathinones are the genotype rs6313 *C/*C of the НТR2A gene.

синтетические катиноны, суицидальное поведение, наркомания, HTR2A(rs6313), HTR1B(rs6296), synthetic cathinones, suicidal behavior, drug addiction, HTR2A (rs6313), HTR1B (rs6296)