STUDY OF GP-15 PHARMACOKINETICS

Abstract

One of the most frequent manifestations of diseases of the cardiovascular system are cardiac arrhythmias. For emergency relief of paroxysmal ventricular arrhythmias, especially those developing against the background of ischemia, class I ant arrhythmic drugs are most often used. Employees of the Department of General and Organic Chemistry of the Perm State Pharmaceutical Academy synthesized a new biologically active compound, a derivative of aryl amides of diethylaminoacetic acid (called monomecaine) - GP-15, which has anti arrhythmic activity. Currently, the compound is undergoing preclinical studies.The purpose of this study was to study the pharmacokinetics of the biologically active compound GP-15 after a single intravenous administration of the substance to laboratory animals. As a result of the research, data were obtained on the quantitative content of GP-15 in the blood plasma of animals after a single intravenous administration, the calculation and analysis of the pharmacokinetics parameters of the compound were carried out. According to the data obtained, the duration of the half-life (T1/2), elimination constant (Kel), total clearance (ClT), total area under the pharmacokinetic curve (AUC), and distribution volume (DV) were calculated.