CHARACTERISTICS OF STATE OF STAT - SIGNALING IN PATIENTS WITH OBESITY
Abstract
Objective: to characterize changes of STAT - signaling system in patients with obesity.Material and methods: The study included 92 patients, of which 24 patients with metabolic syndrome but no diabetes mellitus had progressive forms of obesity I - III degree. The serum concentration of STAT1, STAT 3, STAT 6 proteins in patients was measured by ELISA method.Results: The level of STAT proteins in blood serum in obese patients was: STAT1 - 0.37 [0.25; 0.48] ng / ml, STAT3 - 0.19[0.15; 0.45] ng / ml, STAT6 - 0.16 [0.14; 0.2] ng / ml, which is lower than in healthy individuals, p <0.05. Moreover, in some patients, an increase in the concentration of proteins was registered, which, according to the literature, coincides with a predisposition to Candida, type 1 diabetes, liver disease, allergic reactions, and other diseases.Conclusions: decrease of STAT protein level was found in patients with obesity (STAT1, STAT3, STAT6). Further studies of signal transmission in the JAK / STAT system in adipose tissue may be promising for the diagnosis and new therapeutic approaches to the treatment of obesity, diabetes, liver disease and other diseases.
About the Authors
A. S. Kulakova
ФГБОУ ВО «Орловский государственный университет им. И.С. Тургенева»
Russian Federation
Russian Federation
I. A. Snimshchikova
ФГБОУ ВО «Орловский государственный университет им. И.С. Тургенева»
Russian Federation
Russian Federation
M. O. Plotnikova
ФГБОУ ВО «Орловский государственный университет им. И.С. Тургенева»
Russian Federation
Russian Federation
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Review
For citations:
Kulakova A.S., Snimshchikova I.A., Plotnikova M.O. CHARACTERISTICS OF STATE OF STAT - SIGNALING IN PATIENTS WITH OBESITY. Bashkortostan Medical Journal. 2020;15(2):22-25. (In Russ.)
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