THE FEATURES OF CLINICAL SYMPTOMS AND DYNAMIC OF PRO-INFLAMMATION CYTOKINES IN HEMORRHAGIC FEVER WITH RENAL SYNDROME AMONG ADULTS AND CHILDREN

The aim of research was to estimate the level of pro-inflammation cytokines and clinical symptoms among patients with hemorrhagic fever with renal syndrome (HFRS) in comparative aspects among children and adults depending on period and severity of diseases.The research was conducted among patients with HFRS of middle and heavy severities (67 children and 92 adults).The research of the level of cytokines (TNFб and INF-г) and clinical symptoms was made during different period of the disease -fever, oliguria, polyuria, convalescent.Results. The common dynamic of cytokines in different periods and in case of moderate to severe forms of the diseases among adults and children had equal direction, but we found the differences in changes of the studied parameters in adults and children in some periods of the disease.Both children and adults showed significant changes in cytokine concentration: TNFб increased during oliguria period, but de-creased in polyuria and convalescent periods. TNFб in oliguria and polyuria period and both severity forms in children is significantly higher than in adults.The dynamics of INF-г levels in children and adults by periods and forms of the diseases was practically identical and there wasno significant difference between children and adults. But, during reconvalescence children with severe form of the disease had a significantly higher value of this cytokine than in adults and in comparison with the oliguria period.Adults had more frequently than children such clinical symptoms as weakness (asthenia), headache and pain in loin; in oliguriaperiod - abdominal pain and pain in loin, bleeding from nose, hematuria, leukocyteuria, the inflammations of vessels of white of the eyes; in polyuria period - pain on loin, inflammations of vessels of white of the eyes.Children had more frequency of fever (oliguria period), subfebrile temperature and hematuria (polyuria period) and the polyuriaperiod begun earlier.Conclusions. The research showed the difference in dynamics of the level of cytokines and frequency of clinical symptoms in different periods and severities of diseases among adults and children.

hemorrhagic fever with renal syndrome, cytokines, children, adults

1. Хасанова, Г.М. Актуальные аспекты иммунопатогенеза, витаминно-микроэлементного баланса и лечения геморрагической лихорадки с почечным синдромом: автореф. дис. … д-ра мед. наук. - М., 2012. - 49 с

2. Нехаев, С.Г. Актуальные аспекты геморрагической лихорадки с почечным синдромом (обзор литературы) / С.Г. Нехаев, Л.В. Мельник // Вестник новых медицинских технологий. Электронное издание. ̶ 2018. ̶ № 1. ̶ С. 151-158

3. Геморрагическая лихорадка с почечным синдромом у детей / О.С. Поздеева [и др.] // Практическая медицина. ̶ 2016. ̶ № 8 (100). ̶ С. 53-57

4. Хасанова Г.М. Взаимосвязь уровня циркулирующих цитокинов и микроэлементов у больных геморрагической лихорадкой с почечным синдромом // Саратовский научно-медицинский журнал. - 2011. - Т. 7, № 4. - С. 863-865

5. Взаимосвязи между системой гемостаза и провоспалительными цитокинами при геморрагической лихорадке с почечным синдромом / Р.Т. Мурзабаева, Д.А. Валишин, Ф.Г. Кутлугужина // Международный академический вестник. - 2016. - № 2 (14). - С. 13-17

6. Сиротин Б.З. Геморрагическая лихорадка с почечным синдромом /Б.З. Сиротин. ̶ Хабаровск: Изд-во «РИОТИП». - 1994. ̶ 302 с

7. Tsergouli, K. Immune response in Dobrava-Belgrade virus infections / К. Tsergouli, А Papa // Arch Virol. ̶ 2016. Vol. 12. ̶ № 161 (Dec). ̶ P. 3413-3420

8. Иммунологические особенности воспалительного процесса в остром периоде иксодовых клещевых боррелиозов / Л.Д. Шарифуллина, Р.Т. Мурзабаева, Е.М. Гареев // Медицинский вестник Башкортостана. - 2017. - Т. 12, № 5 (71). - С.69-74

9. Иунихина, О.В. Особенности заболеваемости геморрагической лихорадкой с почечным синдромом среди отдельных групп населения Приморского края / О.В. Иунихина // Здоровье. Медицинская экология. ̶ Наука. ̶ 2016. ̶ № 2 (65). ̶ С. 57-59

10. Avšič-Županc, T. Hantavirus infections / T. Avšič-Županc, A. Saksida, M. Korva// Clin. Microbiol. Infect. ̶ 2019. ̶ S. 21. ̶ P. 6-16

11. Хасанова Г.М. Комплексная реабилитация больных геморрагической лихорадкой с почечным синдромом: монография. - Уфа: Изд-во БашГУ. - 2011. - 272 с

12. Characterization of Biomarker Levels in Crimean-Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome / M. Korva [et al.] // Viruses. ̶ 2019. ̶ Vol. 8, № 11. ̶ P. e686