A MODERN VIEW ON BONE SUBSTITUTES USE AND THE POSSIBILITY OF THEIR OSTEOGENICITY AMPLIFICATION BY CELL TECHNOLOGIES
Abstract
The purpose of the review is to consider the main modern materials used for bone grafting and bone defect replacement and, based on the analysis of literature, to evaluate the results of enhancing their osteoinductive properties by innovative cellular technologies and tissue engineering methods, as well as the possibility of clinical using such implants.Material and methods: the search for literary sources was carried out in open databases of scientific literature PubMed and Cyberleninka by using keywords and their phrases: “reparative osteogenesis”, “bone implant”, “osteoinductance”, “cell technology”, “stem cells» (in Russian and English). The search depth is 15 years.Results: The article provides a literature review of the main modern materials which are used for bone grafting and bone defect replacement. The results of studies aimed at studying the osteoinductive abilities of various bone grafts are analyzed taking into account their material and the design of the structure of the graft. The osteoinductance enhancing by introducing cellular technologies into the graft are considered. The review presents an extensive range of studies, so the results of experiments conducted in vitro and in vivo both in animals and, for a number of grafts, in humans are presented.But, at the same time, it is concluded that most of the results of implant researches, including cellular strategies, were performed only on animals, and recommendations for their clinical use is limited.
About the Authors
T. I. Vlasova
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва»
Russian Federation
Russian Federation
E. V. Arsentieva
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва»
Russian Federation
Russian Federation
G. D. Khudayberenova
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва»
Russian Federation
Russian Federation
D. I. Polyakova
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва»
Russian Federation
Russian Federation
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Review
For citations:
Vlasova T.I., Arsentieva E.V., Khudayberenova G.D., Polyakova D.I. A MODERN VIEW ON BONE SUBSTITUTES USE AND THE POSSIBILITY OF THEIR OSTEOGENICITY AMPLIFICATION BY CELL TECHNOLOGIES. Bashkortostan Medical Journal. 2020;15(2):53-58. (In Russ.)
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