MECHANISM OF DEVELOPMENT AND LINKS OF PATHOGENESIS OF RAYNAUD SYNDROME
Abstract
Raynaud syndrome is an angiotrophoneurosis, which is based on an organic lesion of the vascular wall in the form of hypertrophy of the intima and a decrease in their internal diameter. The syndrome is associated with systemic rheumatic diseases, endocrine and hematological pathology, and individual infections. Clinical manifestations in the form of transient vasospastic reactions are triggered by cold or psychoemotional stress.The purpose of this study is to generalize the currently available information about the prevailing concepts of development ofRaynaud syndrome.The material for writing the article was domestic and foreign sources over the past 10 years. At the same time, methods were used to collect information about the state of the issue, analyze and systematize the data obtained, search for new theories of the pathogenesis of the phenomenon, indicating possible promising directions in the study of this issue.It was found that the pathogenesis of Raynaud syndrome is based on neurovegetative and intravascular disorders, disorders of neoangiogenesis regulation, changes in vascular reactivity. Pathological processes are caused by the progression of major diseases, as well as the action of a number of predisposing factors. Ultimately, this leads to structural changes in the vascular wall and the development of ischemia of adjacent tissues.
About the Authors
L. N. Karabanova
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарева»
Russian Federation
Russian Federation
S. V. Bukin
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарева»
Russian Federation
Russian Federation
M. V. Ruzmaikin
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарева»
Russian Federation
Russian Federation
E. A. Shamrova
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарева»
Russian Federation
Russian Federation
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Review
For citations:
Karabanova L.N., Bukin S.V., Ruzmaikin M.V., Shamrova E.A. MECHANISM OF DEVELOPMENT AND LINKS OF PATHOGENESIS OF RAYNAUD SYNDROME. Bashkortostan Medical Journal. 2020;15(2):66-69. (In Russ.)
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