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GASTRODUODENAL ULGER BLEEDING: CURRENT STATE OF PROBLEM

Abstract

The article presents a review of foreign literature over the past 15 years on the problem of acute ulcerative gastroduodenal bleeding. Diagnostic issues are described in detail, methods for studying the first and second lines, diagnostic significance of gastroduodenoscopy, computed tomography, angiography of visceral branches of the abdominal aorta are considered. Endoscopy, as a rule, is a method of diagnosing the first line, the significance of CT is not completely determined. In difficult cases, in severe patients, according to the results of an interdisciplinary discussion, angiography can be used as a diagnostic method. The analysis of existing methods of stratification of the severity of bleeding, the presence and threat of recurrence of bleeding has been performed. The characteristic, indications for endoscopic, conservative, surgical and endovascular methods of hemostasis, the sequence of their application are presented. Particular attention is paid to the issues of forecasting, the choice of therapeutic tactics and prevention of recurrence of bleeding.

About the Authors

Sh. V. Timerbulatov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


M. V. Timerbulatov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


R. B. Sagitov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


V. M. Timerbulatov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


A. R. Gafarova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


References

1. Lanas A. Peptic ulcer disease/ A. Lanas, F. Chan // Lancet. - 2017. - V. 390. - P. 613-624

2. Al Dhahab H State-of-the-art management of acute bleeding peptic ulcer disease /H. Al Dhahab [et all.]// Saudi J Gastroenterol. - 2013. - V. 19. - P.195-204

3. Shingina A Systematic review: the presenting international normalised ratio (INR) as a predictor of outcome in patients with upper nonvariceal gastrointestinal bleeding/ A. Shingina [et all.] // Aliment Pharmacol Ther. - 2011. - V.33. - P.1010-1018

4. Stunell H. The role of computerized tomography in the evaluation of gastrointestinal bleeding following negative or failed endoscopy: a review of current status/ H. Stunell [et all.] //J Postgrad Med. - 2008. - V.54. - P.126-134

5. Laing C J Acute gastrointestinal bleeding: emerging role of multidetector CT angiography and review of current imaging techniques/ C.J.Laing [et all.] // Radiographics. - 2007. - V. 27. - P.1055-1070

6. Cook DJ Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis/ D.J. Cook [et all.] // Gastroenterology. -1992.-V. 102.-P.139-148

7. Marmo R Outcome of endoscopic treatment for peptic ulcer bleeding: Is a second look necessary? A meta-analysis/R. Marmo [et all.] // Gastrointest Endosc. -2003.-V. 57.-P.62-67

8. Tsoi KK Endoscopy for upper gastrointestinal bleeding: is routine second-look necessary? / KK Tsoi, PW Chiu, JJ Sung //Nat Rev Gastroenterol Hepatol.- 2009.-№.6.-P.717-722

9. Wong SH Management of GI emergencies: peptic ulcer acute bleeding/ SH Wong, JJ.Sung //Best Pract Res Clin Gastroenterol. - 2013.- V.27.-P.639-647

10. Stanley AJ Multicentre comparison of the Glasgow Blatchford and Rockall Scores in the prediction of clinical end-points after upper gastrointestinal haemorrhage/ AJ Stanley [et all.] // Aliment Pharmacol Ther. -2011.-V.34.-P.470-475

11. Mokhtare M Comparison of Glasgow-Blatchford score and full Rockall score systems to predict clinical outcomes in patients with upper gastrointestinal bleeding /M. Mokhtare [et all.]// Clin Exp Gastroenterol. -2016.-№9.-P.337-343

12. Nelms DW The Acute Upper Gastrointestinal Bleed/ DW Nelms, CA Pelaez //Surg Clin North Am.- 2018.-V. 98.-P.1047-1057

13. Spahn DR The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition/ DR Spahn // Crit Care. -2019.-V.23.-P.98

14. Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38:316-21

15. Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for uppergastrointestinalhaemorrhage. Lancet. 2000;356:1318-21

16. Baradarian R, Ramdhaney S, Chapalamadugu R, Skoczylas L, Wang K, Rivilis S, Remus K, Mayer I, Iswara K, Tenner S. Early intensive resuscitation of patients with upper gastrointestinal bleeding decreases mortality. Am J Gastroenterol. 2004; 99:619-22

17. Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C, Graupera I, Poca M, Alvarez-Urturi C, Gordillo J, Guarner-Argente C, Santalo M, Muniz E, Guarner C. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013; 368:11-21

18. Martinez-Alcala A, Monkemuller K. Emerging Endoscopic Treatments for Nonvariceal Upper Gastrointestinal Hemorrhage. Gastrointest Endosc Clin N Am. 2018; 28: 307-20

19. Barkun AN, Martel M, Toubouti Y, Rahme E, Bardou M. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses. Gastrointest Endosc. 2009;69:786-99

20. Sacks HS, Chalmers TC, Blum AL, Berrier J, Pagano D. Endoscopic hemostasis. An effective therapy for bleeding peptic ulcers. JAMA. 1990; 264:494-9

21. Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB. International Gastrointestinal Bleeding C. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleed- ing: international multicentre prospective study. BMJ. 2017; 356:i6432

22. Marmo R, Rotondano G, Piscopo R, Bianco MA, D'Angella R, Cipolletta L. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol. 2007; 102:279-89 quiz 469

23. Vergara M, Bennett C, Calvet X, Gisbert JP. Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers. Cochrane Database Syst Rev 2014:CD005584

24. Shi K, Shen Z, Zhu G, Meng F, Gu M, Ji F. Systematic review with network meta-analysis: dual therapy for high-risk bleeding peptic ulcers. BMC Gastroenterol. 2017;17:55

25. Sung JJ, Chiu PW, Chan FKL, Lau JY, Goh KL, Ho LH, Jung HY, Sollano JD, Gotoda T, Reddy N, Singh R, Sugano K, Wu KC, Wu CY, Bjorkman DJ, Jensen DM, Kuipers EJ, Lanas A. Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018. Gut. 2018;67:1757-68

26. Bleau BL, Gostout CJ, Sherman KE, Shaw MJ, Harford WV, Keate RF, Bracy WP, Fleischer DE. Recurrent bleeding from peptic ulcer associated with adherent clot: A randomized study comparing endoscopic treatment with medical therapy. Gastrointestinal Endoscopy. 2002; 56:1-6

27. Manno M, Mangiafico S, Caruso A, Barbera C, Bertani H, Mirante VG, Pigo F, Amardeep K, Conigliaro R. First-line endoscopic treatment with OTSC in patients with high-risk non-variceal upper gastrointestinal bleeding: preliminary experience in 40 cases. Surg Endosc. 2016; 30:2026-9

28. Richter-Schrag HJ, Glatz T, Walker C, Fischer A, Thimme R. First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases. World J Gastroenterol. 2016; 22:9162-71

29. Wedi E, Fischer A, Hochberger J, Jung C, Orkut S, Richter-Schrag HJ. Multicenter evaluation of first-line endoscopic treatment with the OTSC in acute non-variceal upper gastrointestinal bleeding and comparison with the Rockall cohort: the FLETRock study. Surg Endosc. 2018; 32:307-14

30. Manta R, Galloro G, Mangiavillano B, Conigliaro R, Pasquale L, Arezzo A, Masci E, Bassotti G, Frazzoni M. Over-the-scope clip (OTSC) represents an effective endoscopic treatment for acute GI bleeding after failure of conventional techniques. Surg Endosc. 2013; 27:3162-4

31. Skinner M, Gutierrez J, Neumann H, Wilcox C, Burski C, Mönkemüller K. Over-the-scope clip placement is effective rescue therapy for severe acute upper gastrointestinal bleeding. Endoscopy International Open. 2014; 2:E37-40

32. Chan SM, Chiu PW, Teoh AY, Lau JY. Use of the Over-The-Scope Clip for treatment of refractory upper gastrointestinal bleeding: a case series. Endoscopy. 2014;46:428-31

33. Jensen DM, Ohning GV, Kovacs TO, Ghassemi KA, Jutabha R, Dulai GS, Machicado GA. Doppler endoscopic probe as a guide to risk stratification and definitive hemostasis of peptic ulcer bleeding. GastrointestEndosc. 2016; 83:129-36

34. Jensen DM, Kovacs TOG, Ohning GV, Ghassemi K, Machicado GA, Dulai GS, Sedarat A, Jutabha R, Gornbein J. Doppler Endoscopic Probe Monitoring of Blood Flow Improves Risk Stratification and Outcomes of Patients With Severe Nonvariceal Upper Gastrointestinal Hemorrhage. Gastroenterology. 2017;152:1310-8 e1

35. Selby N, Kubba A, Hawkey C. Acid suppression in peptic ulcer haemorrhage: a 'meta-analysis'. Alimentary Pharmacology and Therapeutics. 2000;14:1119-26

36. Lin HJ, Lo WC, Cheng YC, Perng CL. Role of intravenous omeprazole in patients with high-risk peptic ulcer bleeding after successful endoscopic epinephrine injection: a prospective randomized comparative trial. Am J Gastroenterol. 2006;101:500-5

37. Sung JJY. Intravenous Esomeprazole for Prevention of Recurrent Peptic Ulcer Bleeding. Ann Intern Med. 2009;150:455

38. Laine L, McQuaid KR. Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials. Clin Gastroenterol Hepatol. 2009;7:33-47 quiz 1-2

39. Neumann I, Letelier LM, Rada G, Claro JC, Martin J, Howden CW, YuanY, Leontiadis GI. Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database Syst Rev 2013:CD007999

40. Sreedharan A, Martin J, Leontiadis GI, Dorward S, Howden CW, Forman D, Moayyedi P. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. Cochrane Database Syst Rev 2010:CD005415

41. Lau JYW, Barkun A, D-m F, Kuipers EJ, Yang Y-s, Chan FKL. Challenges in the management of acute peptic ulcer bleeding. Lancet. 2013;381:2033-43

42. Theivanayagam S, Lim RG, Cobell WJ, Gowda JT, Matteson ML, Choudhary A, Bechtold ML. Administration of erythromycin before endoscopy in upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials. Saudi J Gastroenterol. 2013;19:205-10

43. Szary NM, Gupta R, Choudhary A, Matteson ML, Arif M, Hammad HT, Bechtold ML. Erythromycin prior to endoscopy in acute upper gastrointestinal bleeding: a meta-analysis. Scand J Gastroenterol. 2011;46:920-4

44. Barkun AN, Bardou M, Martel M, Gralnek IM, Sung JJ. Prokinetics in acute upper GI bleeding: a meta-analysis. GastrointestEndosc. 2010;72:1138-45

45. Aljebreen AM, Fallone CA, Barkun AN, for the Ri. Nasogastric aspirate predicts high-risk endoscopic lesions in patients with acute upper-GI bleeding. Gastrointestinal Endoscopy. 2004;59:172-8

46. Ali T, Roberts DN, Tierney WM. Long-term safety concerns with proton pump inhibitors. Am J Med. 2009;122:896-903

47. Chan FKL, Sung JJY, Sydney Chung SC, To KF, Yung MY, Leung VKS, Lee YT, Chan CSY, Li EKM, Woo J. Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers. Lancet. 1997;350:975-9

48. Lau JY, Sung JJ, Lam YH, Chan AC, Ng EK, Lee DW, Chan FK, Suen RC, Chung SC. Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers. N Engl J Med. 1999;340:751-6

49. Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, Rotondano G, Hucl T, Dinis-Ribeiro M, Marmo R, Racz I, Arezzo A, Hoffmann RT, Lesur G, de Franchis R, Aabakken L, Veitch A, Radaelli F, Salgueiro P, Cardoso R, Maia L, Zullo A, Cipolletta L, Hassan C. Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2015;47:a1-46

50. Cheynel N, Peschaud F, Hagry O, Rat P, Ognois-Ausset P, Favre JP. Ulcèregastroduodénalhémorragique :résultats du traitement chirurgical1Communication présentée à l'Académienationale de chirurgie au cours de la séance du 31 janvier 2001. Annales de Chirurgie. 2001;126:232-5

51. Loffroy R, Favelier S, Pottecher P, Estivalet L, Genson PY, Gehin S, Cercueil JP, Krause D. Transcatheter arterial embolization for acute nonvariceal upper gastrointestinal bleeding: Indications, techniques and outcomes. Diagn Interv Imaging. 2015;96:731-44

52. Mejaddam AY, Cropano CM, Kalva S, Walker TG, Imam AM, Velmahos GC, de Moya MA, King DR. Outcomes following “rescue” superselectiveangioembolization for gastrointestinal hemorrhage in hemodynamically unstable patients. J Trauma Acute Care Surg. 2013;75:398-403

53. Loffroy R, Guiu B, D'Athis P, Mezzetta L, Gagnaire A, Jouve JL, Ortega-Deballon P, Cheynel N, Cercueil JP, Krause D. Arterial embolotherapy for endoscopically unmanageable acute gastroduodenal hemorrhage: predictors of early rebleeding. Clin Gastroenterol Hepatol. 2009;7:515-23

54. Kyaw M, Tse Y, Ang D, Ang TL, Lau J. Embolization versus surgery for peptic ulcer bleeding after failed endoscopic hemostasis: a meta-analysis. Endosc Int Open. 2014;2:E6-E14

55. Beggs AD, Dilworth MP, Powell SL, Atherton H, Griffiths EA. A systematic review of transarterial embolization versus emergency surgery in treatment of major nonvariceal upper gastrointestinal bleeding. Clin Exp Gastroenterol. 2014;7:93-104

56. Tarasconi A, Baiocchi GL, Pattonieri V, Perrone G, Abongwa HK, Molfino S, Portolani N, Sartelli M, Di Saverio S, Heyer A, Ansaloni L, Coccolini F, Catena F. Transcatheter arterial embolization versus surgery for refractory non-variceal upper gastrointestinal bleeding: a meta-analysis. World J Emerg Surg. 2019;14:3

57. Nykänen T, Peltola E, Kylänpää L, Udd M. Bleeding gastric and duodenal ulcers: case-control study comparing angioembolization and surgery. Scandinavian Journal of Gastroenterology. 2017;52:523-30

58. Aina R, Oliva VL, Therasse É, Perreault P, Bui BT, Dufresne M-P, Soulez G. Arterial Embolotherapy for Upper Gastrointestinal Hemorrhage: Outcome Assessment. Journal of Vascular and Interventional Radiology. 2001;12:195-200

59. Padia SA, Geisinger MA, Newman JS, Pierce G, Obuchowski NA, Sands MJ. Effectiveness of coil embolization in angiographically detectable versus non-detectable sources of upper gastrointestinal hemorrhage. J VascIntervRadiol. 2009;20:461-6

60. Walsh R. Role of angiography and embolization for massive gastroduodenal hemorrhage. J Gastrointest Surg. 1999;3:61-6

61. Defreyne L, Vanlangenhove P, Decruyenaere J, Van Maele G, De Vos M, Troisi R, Pattyn P. Outcome of acute nonvariceal gastrointestinal haemorrhage after nontherapeutic arteriography compared with embolization. Eur Radiol. 2003;13:2604-14

62. Laursen SB, Hansen JM, Andersen PE, Schaffalitzky de Muckadell OB. Supplementary arteriel embolization an option in high-risk ulcer bleeding--a randomized study. Scand J Gastroenterol. 2014;49:75-83

63. Lau JYW, Pittayanon R, Wong KT, Pinjaroen N, Chiu PWY, Rerknimitr R, Holster IL, Kuipers EJ, Wu KC, Au KWL, Chan FKL, Sung JJY. Prophylacti angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial. Gut. 2018

64. Mille M, Huber J, Wlasak R, Engelhardt T, Hillner Y, Kriechling H, Aschenbach R, Ende K, Scharf JG, Puls R, Stier A. Prophylactic Transcatheter Arterial Embolization After Successful Endoscopic Hemostasis in the Management of Bleeding Duodenal Ulcer. J Clin Gastroenterol. 2015;49:738-45

65. Lolle I, Møller MH, Rosenstock SJ. Association between ulcer site and outcome in complicated peptic ulcer disease: a Danish nationwide cohort study. Scand J Gastroenterol. 2016;51:1165-71

66. Schroder VT, Pappas TN, Vaslef SN, De La Fuente SG, Scarborough JE. Vagotomy/drainage is superior to local oversew in patients who require emergency surgery for bleeding peptic ulcers. Ann Surg. 2014;259:1111-8

67. Yoon H, Lee DH, Jang ES, Kim J, Shin CM, Park YS, Hwang JH, Kim JW, Jeong SH, Kim N. Optimal initiation of Helicobacter pylori eradication in patients with peptic ulcer bleeding. World J Gastroenterol. 2015;21:2497-503

68. Satoh K, Yoshino J, Akamatsu T, Itoh T, Kato M, Kamada T, Takagi A, Chiba T, Nomura S, Mizokami Y, Murakami K, Sakamoto C, Hiraishi H, Ichinose M, Uemura N, Goto H, Joh T, Miwa H, Sugano K, Shimosegawa T. Evidence-based clinical practice guidelines for peptic ulcer disease 2015. J Gastroenterol. 2016;51:177-94

69. Gisbert JP, Khorrami S, Carballo F, Calvet X, Gene E, Dominguez-Munoz E. Meta-analysis: Helicobacter pylori eradication therapy vs. antisecretory non-eradication therapy for the prevention of recurrent bleeding from peptic ulcer. AlimentPharmacolTher. 2004;19:617-29

70. Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ, European Helicobacter Study G. Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut. 2012;61:646-64

71. Zagari RM, Romano M, Ojetti V, Stockbrugger R, Gullini S, Annibale B, Farinati F, Ierardi E, Maconi G, Rugge M, Calabrese C, Di Mario F, Luzza F, Pretolani S, Savio A, Gasbarrini G, Caselli M. Guidelines for the management of Helicobacter pylori infection in Italy: The III Working Group Consensus Report 2015. DigLiverDis. 2015;47:903-12

72. Di Caro S, Fini L, Daoud Y, Grizzi F, Gasbarrini A, De Lorenzo A, Di Renzo L, McCartney S, Bloom S. Levofloxacin/amoxicillinbased schemes vs quadruple therapy for Helicobacter pylori eradication in second-line. World J Gastroenterol. 2012;18:5669-78

73. Gatta L, Vakil N, Vaira D, Scarpignato C. Global eradication rates for Helicobacter pylori infection: systematic review and metaanalysis of sequential therapy. BMJ. 2013;347:f4587

74. Das R, Sureshkumar S, Sreenath GS, Kate V. Sequential versus concomitant therapy for eradication of Helicobacter Pylori in patients with perforated duodenal ulcer: A randomized trial. Saudi J Gastroenterol. 2016;22:309-15


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Timerbulatov Sh.V., Timerbulatov M.V., Sagitov R.B., Timerbulatov V.M., Gafarova A.R. GASTRODUODENAL ULGER BLEEDING: CURRENT STATE OF PROBLEM. Bashkortostan Medical Journal. 2020;15(2):85-96. (In Russ.)

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ISSN 1999-6209 (Print)