ON THE FEATURES OF THE COURSE OF THE ULCERATIVE COLITIS

Abstract

The aim: to evaluate the clinical course and results of treatment of patients with ulcerative colitis.Material and methods: 144 patients with ulcerative colitis. The diagnosis of the disease was made on the basis of the clinic, ultrasound data, endoscopy, histology, and surgical interventions. In more than half of the cases (64%), the duration of the disease did not exceed 5 years. The recurrent course of the ulcerative colitis was detected in 41.6% of cases.Results and conclusions: mild degree of the disease was observed in 28.4%, the medium severity - in 44.8%, severe degree - in26.8% of cases. The surgical treatment was performed in 57 patients (39.5%). The scope of the operation was limited to hemicolectomy, subtotal colectomy and colproctomy. In 61.4% of cases, the operation ended with the imposition of an ileostomy. The mortality was 23%, mainly in severe degree of the disease. During histological examination of the resected reparations, in addition to ulcerative-destructive and inflammatory changes in the mucous membrane of the colon, dysplastic changes in the epithelium of the glands were often found. This precancerous process is a precursor of colorectal cancer and is characterized by impaired proliferation and differentiation of the glandular epithelium.