WEST SYNDROME: SOME PREDICTIVE FACTORS OF THERAPY EFFECTIVENESS

Abstract

Aim: to reveal the dependence of the effectiveness of therapy for West syndrome (WS) with various antiepileptic drugs (AEDs)on the timing of treatment initiation and the age of onset of WS.Material and methods. 150 children with West syndrome treated at the Children's City Hospital No. 8 for the period 2000-2015 were examined. The children were divided into subgroups depending on the early or late start of treatment and the age of onset of the disease. Group I included 90 patients who received tetracosactide in combination with other PES, and group II was representedby 60 children who received other PES without the use of hormones. The risk ratios were calculated using Resman 5.3 to evaluatethe effectiveness (follow-up of patients for at least a year). A favorable outcome of treatment was considered clinical remission - the absence of seizures.Results. The efficacy of tetracosactide after 2 weeks, 2, 6 and 12 months in group I is the same regardless of the time of initia-tion of therapy (p> 0.05). A greater number of seizure-free children were found in group I, in whom WS began at the age of 6-12 months (p <0.05).Conclusions. The effectiveness of WS therapy with the inclusion of tetracosactide does not depend on the timing of the initia-tion of therapy and it is higher in the event of infantile spasms at the age of 6-12 months with short-term follow-up.