STRUCTURAL AND FUNCTIONAL FEATURES OF ACUTE MYOCARDIAL INJURY IN NEW CORONAVIRUS INFECTION

Objective. To analyze the features of the influence of the new coronavirus infection COVID-19 on the myocardium based on materials of domestic and foreign literature.Material and methods. A study of the available literature data was carried out and the pathogenetic features of myocardial damage in patients with coronavirus infection caused by SARS-CoV-2, diagnostic methods and possible directions of therapeutic correction of cardiovascular pathology were determined.Conclusion. The clinical course of COVID-19 is characterized not only by the respiratory tract damage, but also by heart and vascular damage, which can be represented by myocarditis, pericarditis, endocarditis, coronariitis and thrombendocarditis. The leading role in the pathogenesis of damage to the cardiovascular system is played by the renin-angiotensin-aldesterone system, endogenous catecholamine adrenergic stress and endothelial damage. Myocardial damage is confirmed by high levels of serum creatinine, N-terminal natriuretic peptide, highly sensitive troponin T, and the progression of diastolic dysfunction. The literature data obtained indicate the need to further study of diagnostic methods and treatment of patients with COVID-19 at the inpatient and outpatient stages of management.

COVID-19, NT-proBNP, endocarditis, myocarditis, coronariitis, endothelial dysfunction, troponins, angiotensin converting enzyme

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