EFFECT OF 5-OXYMETHYLURACIL (PYRIMIDINE AGENT) ON CENTRAL HEMODYNAMIC VALUES IN PATIENTS IN EARLY AND LONG-TERM MYOCARDIAL SURGICAL REVASCULARIZATION

Objective. To study the effect of 5-Oxymethyluracil, medication with angiogenic properties, on the central hemodynamic values in patients in early and long-term myocardial surgical revascularization.

Material and methods. Two groups of patients have been included in a randomized prospective study as follows: the core group comprised of 87 patients in the perioperative period of coronary artery bypass graft (CABG) surgery (5 days prior to and within 14 days after the surgical procedure). In addition to standard medical therapy, patients of the core group have been obtaining 5- Oxymethyluracil medication. The control group (comprised of 81 patients) have been obtaining standard medical therapy. The groups were comparable in terms of gender, age, principal clinical and functional specifications and features of surgery. Echocardi- ography was performed in patients before surgery (upon admission to the vascular surgery department) and after surgery (after 2 months and after 15-17 years); the dynamics of end-systolic volume of the left ventricle (LV ESV), end-diastolic volume of the left ventricle (LV EDV) and left ventricular ejection fraction (LVEF) were evaluated.

Results. In the core group of patients as compared with the preoperative values, within the period of 2 months after the CABG, a decrease in the EDV occurred by 6.88% (p=1.0), in the ESV by 11.61% (p=0.0380), an increase in the EF was by 5.03% (p=1); within the period of 16-18 years after the CABG, the EDV increased by 2.57% (p=1.0), the ESV increased by 8.72% (p=1.0), the EF decreased by 12.49% (p=0.0058). With the period of 2 months after the surgery, a decrease in the EDV by 4.48% (p=1.0), in the ESV by 6.1% (p=1.0), the EF by 0.38% (p=1.0) was observed in the control group, and after 16-18 years, the EDV increased by 5.43% (p=1.0), the ESV increased by 13.17% (p=1.0), and the EF decreased by 19.57% (p=0.0127).

Conclusion. Сontractile function retention of the left ventricular myocardium in the long-term myocardial surgical revascularization (patients’ follow-up period is 16-18 years) in the course of using 5-Oxymethyluracil medication occurs predominantly due to the reduction of the end-systolic volume in the early postoperative period.

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