PERFUSION COMPUTED TOMOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF COLON DISEASES

The aim of the research was to study the possibility of the use of perfusion computed tomography in patients with various lesions of the colon wall.

Material and methods. 46 patients aged 34-79 years with diverticular colon disease (DCD) were selected and divided into 3 groups. The first group consisted of persons with an unchanged wall of the colon (5 people), the second group was composed of 34 patients with DCD complicated by diverticulitis, the third group consisted of 7 patients with malignant tumors of the colon. All studies were performed on an Optima CT 660 (GE) multislice computed tomograph with 128 detector rows and a slice thickness of 0.65 mm. Initially, scanning was carried out in the native mode selecting the area of interest, and then the perfusion was carried out. The images obtained during dynamic contrasting were analyzed on the Advantage Workstation using the CT Perfusion 4D application with the determination of blood volume and velocity parameters in 1 cubic centimeter of wet substance per minute.

Results and discussion. According to the data obtained, the indicators of the regional blood flow rate (Blood Flow – BF) in malignant tumors increased by an average of 5.6 times compared to the unchanged colon wall. Indicators of the volume of regional blood flow (Blood Volume – BV) in malignant tumors compared with the unchanged colon wall increased by an average of 14.2 times. The indicators of the average blood flow transit Time (Mean Transit Time – MTT) in malignant tumors increased by 4.3 times compared to the unchanged colon wall.

Conclusions. The technique of perfusion computed tomography allows you to register the difference in the indicators of regional blood flow in neoplastic processes, which in turn allows for a more accurate differential diagnosis.

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