MORPHOFUNCTIONAL CHARACTERISTICS OF THE GASTRODUODENAL ZONE IN PERSONS WITH AN EARLY ONCE OF TOBACCO SMOKING

Abstract

Purpose of the study. Comprehensive assessment of the effect of active tobacco smoking on the gastroduodenal zone in individuals with early onset of tobacco smoking.Material and methods. A questionnaire was carried out using the Gastrointestinal Symptoms Rating Scale (GSRS) and the Eating Behavior Questionnaire (DEBQ), followed by fibrogastroduodenoscopy (FGDS) using an Olympus CV-170 (Optera) apparatus with histological determination of H. pylori and pH-metry. For pairwise comparison of two independent samples, the Mann-Whitney U-test was used, for qualitative ones - the Chi-square test with Yates' correction for 2×2 contingency tables with the calculation of the odds ratio (Odds Ratio).Results. 60 young people were examined; the average age was 21.3 + 4.2 years. The average pack / year index for smokers was3.2±2.8. The examined people were divided into 2 groups: the first - 28 smokers, the second - 32 people (control). Questioning according to the GSRS scale and according to the DEBQ questionnaire did not show statistically significant differences in the groups. According to the data of pH-metry and quantitative determination of H. pylori, lower pH values were found in the group of smokers (p = 0.002), persons with a high degree of H. pylori contamination (+++) were also significantly more frequent (p = 0.031,95%, OR = 5.37; CI 1.30-22.17).Conclusions. Further research is required with a large coverage of the surveyed with the subsequent development of new methods of prevention, diagnosis and treatment of both nicotine addiction itself in actively smoking young people, and the consequences of tobacco smoking in the early stages.