CURRERT ASPECTS OF HUMAN CHRONOADAPTATION AND DESASAPTATION
Abstract
Purpose: to analyze highlight previous and recent literature studies of chronoadaptation problem of the human body by daily and seasonal cycles.Material and methods. The review examines the results of 11 RSCI and 36 PubMed scientific sources by the role of genetically determined structures that regulate the 12-hour, circadian (daily) and circannual (annual) biorhythms of the human body.Results and discussion. The autonomous cellular regulation is caused by self-regulating molecular rhythm generators (oscillators) - circadian genes. They determine the diurnal and seasonal changes in photoperiod changes under the influence of the hypothalamus and pars tuberaslis of the pituitary gland. Cells-organs-organisms of mammals and humans under the influence of the «biological clock» are able to adapt to cyclic processes and stressors, can anticipate them and reform. The disturbance of the coordinated work of the «biological clock» leads to disorders of adaptation, the formation of metabolic disorders, cardiovascular diseases and pathology of the nervous system.Conclusions. Thus, the study of the influence of the laws of adaptation of physiological functions during a certain period of time(day, seasons), with changes in environment (photoperiod), allows a deeper understanding of the etiopathogenesis of diseases, and, therefore, novel therapeutic opportunities for circadian medicine.
About the Author
F. S. Datieva
Институт биомедицинских исследований - филиал ФГБУН ФНЦ Владикавказский научный центр РАН
Russian Federation
Russian Federation
References
1. Halberg, F. Chronobiology in 1975 / F. Halberg // Chronobiologia. - 1976. - Vol. 3, № 1. - Р. 1-11
2. Ашофф, Ю. Биологические ритмы: в 2-х т. / Ю. Ашофф. - М.: Мир, 1984. - Т. 1: пер. с англ. - 414 с
3. Питтендрай, К. Циркадные ритмы и циркадная организация живых систем / К. Питтендрай // Биологические часы. - М.: Мир, 1964. - С. 263-306
4. Хроноархитектоника биоритмов и среда обитания / Н.А. Агаджанян [и др.]. - Тюмень, Изд-во: Тюменский государственный университет. - 1998. - 168 с
5. The human blood pressure chronome: a biological gauge of aging / D. Gubin [et al.] // In Vivo. - 1997. - Vol. 11, № 6. - P. 485-494
6. Романов, Ю.А. Временная организация биологических систем / Ю.А. Романов // Биологические ритмы. - М.: Медицина, 1980. - С.10-56
7. Хронобиология и хрономедицина: руководство / под ред. С.И. Рапопорта, В.А. Фролова, Л.Г. Хетагуровой. - М.: ООО «Медицинское информационное агентство», 2012. - 480 с
8. Kim, Y.H. Transcriptional control of circadian rhythms and metabolism: a matter of time and space / Y.H. Kim, M.A. Lazar // Endocr. Rev. - 2020. - Vol. 41, № 5. - Р. 707-732
9. Kuhlman, S.J.Introduction to Chronobiology / S.J Kuhlman, L.M. Craig, J.F. Duffy // Cold Spring Harb. Perspect. Biol. - 2018. - Vol. 10, № 9. - P. a033613
10. Bargiello, T.A. Restroration of circadian behavioural rhythms by gene transfer in Drosophila / T.A. Bargiello, F.R. Jackson, M.W. Young // Nature. - 1984. - Vol. 312. - P. 752-754
11. Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome / C. Vollmers [et al.] // Cell Metab. - 2012. - Vol. 16, № 6. - Р. 833-845
12. Takahashi, J.S. Transcriptional architecture of the mammalian circadian clock /j.S. Takahashi // Nat. Rev. Genet. - 2017. - Vol. 18, № 3. - P. 164-179
13. Diurnal transcriptome atlas of a primate across major neural and peripheral tissues / L.S. Mure [et al.] // Science. - 2018. - Vol. 359, № 6381. - P. eaao0318
14. Circadian gene expression atlas in mammals: implications for biology and medicine / R. Zhang [et al.] // Proc. Natl. Acad. Sci. USA. - 2014. - Vol. 111, № 45. - P. 16219-16224
15. Glucocorticoid signaling synchronizes the liver circadian transcriptome / A.B. Reddy [et al.] // Hepatology. - 2007. - Vol. 45, № 6. - P. 1478-1488https://doi.org/10.1002/hep.21571
16. Karamitri, A. Melatonin in type 2 diabetes mellitus and obesity / A. Karamitri, R. Jockers // Nat. Rev. Endocrinol. - 2019. - Vol. 15, № 2. - P. 105-125
17. Entrainment of the circadian clock in the liver by feeding / K.A. Stokkan [et al.] // Science. - 2001. - Vol. 291. - P. 490-493
18. High-fat diet disrupts behavioral and molecular circadian rhythms in mice / A. Kohsaka [et al.] // Cell Metab. - 2007. - Vol. 6, № 5. - P. 414-421
19. Challet, E. The circadian regulation of food intake / E. Challet // Nat. Rev. Endocrinol. - 2019. - Vol. 15, № 7. - P. 393-405
20. FGF21 regulates metabolism and circadian behavior by acting on the nervous system / A.L. Bookout [et al.] // Nat. Med. - 2013. - Vol. 19, № 9. - P. 1147-1152
21. Tsuneki, H. Chronopathophysiological implications of orexin in sleep disturbances and lifestyle-related disorders / H. Tsuneki, T. Wada, T. Sasaoka // Pharmacol. Ther. - 2018. - Vol. 186. - P. 25-44
22. Zhu, B. A cell-autonomous mammalian 12 hr clock coordinates metabolic and stress rhythms / B. Zhu // Cell Metab. - 2017. - Vol. 25, № 6. - P. 1305-1319.e9
23. Zhu, B. Unveiling «Musica Universalis» of the cell: a brief history of biological 12-hour rhythms / B. Zhu, C.C. Dacso, B.W. O’Malley //j. Endocr. Soc. - 2018. - Vol. 2, № 7. - P. 727-752
24. Harmonics of circadian gene transcription in mammals / M.E. Hughes [et al.] // PLoS Genet. - 2009. - Vol. 5, № 4. - P. e1000442
25. Buhr, E.D. Temperature as a universal resetting cue for mammalian circadian oscillators / E.D. Buhr, S.H. Yoo, J.S. Takahashi // Science. - 2010. - Vol. 330, № 6002. - P. 379-385
26. Wood, S. The pars tuberalis: the site of the circannual clock in mammals? / S. Wood, A. Loudon // General and Comparative Endocrinology. - 2018. - Vol. 258. - P. 222-235
27. Lincoln, G. A brief history of circannual time / G. Lincoln // Journal of Neuroendocrinology. - 2019. - Vol. 31, № 3. - P. e12694
28. Widespread seasonal gene expression reveals annual differences in human immunity and physiology / X.C. Dopico [et al.] // Nature Communications. - 2015. - Vol. 6. - P. 7000
29. Chen, J. Light and hormones in seasonal regulation of reproduction and mood /j. Chen, K. Okimura, T. Yoshimura // Endocrinology. - 2020. - Vol. 161, № 9. - P. bqaa130
30. Mishra, I. Circadian basis of seasonal timing in higher vertebrates [Electronic resource] / I. Mishra, V. Kumar // Biological Rhythm Research. - 2017. - P. 723-738. URL: https://www.tandfonline.com/doi/full/10.1080/09291016.2017.1345447?scroll=top&needAccess=true (accessed 01.12.2021)
31. Хронопатология (экспериментальные и клинические аспекты) / Л.Г. Хетагурова [и др.]. - М.: Наука, 2004. - 355 с
32. Schroeder, A.M. How to fix a broken clock // A.M. Schroeder, C.S. Colwell // Trends Pharmacol. Sci. - 2013. - Vol. 34, № 11. - P. 605-619
33. Агаджанян, Н.А. Биоритмы. Среда обитания. Здоровье / Н.А. Агаджанян, И.В. Радыш. - М.: РУДН, 2013. - 362 с
34. Казначеев, В.П. Современные аспекты адаптации / В.П. Казначеев. - Новосибирск: Наука, 1980. - 191 с
35. Степанова, С.И. Биоритмологические аспекты проблемы адаптации / С.И. Степанова. - М.: Наука, 1986. - 241 с
36. Оранский, И.Е. Хронобиологические аспекты ИБС / И.Е. Оранский.- Свердловск, 1988. - С. 73-89
37. Zhang, J. Circadian regulation of cardiac physiology: rhythms that keep the heart beating /j. Zhang, J. Chatham, M.E. Young // Annu. Rev. Physiol. - 2020. - Vol. 82. - P. 79-101
38. Impact of the human circadian system, exercise, and their interaction on cardiovascular function / F.A. Scheer [et al.] // PNAS. - 2010. - Vol. 107, № 47. - P. 20541-20546
39. Меерсон, Ф.3. Феномен адаптационной стабилизации структур и защита сердца / Ф.3. Меерсон, И.Ю. Малышев. - М.: Наука, 1993. - 243 с
40. Roenneberg, T. Social jetlag and obesity / T. Roenneberg // Curr. Biol. - 2012. - Vol. 22, № 10. - P. 939-943
41. Chinoy, E.D. Unrestricted evening use of light-emitting tablet computers delays self-selected bedtime and disrupts circadian timing and alertness // E.D. Chinoy, J.F. Duffy, C.A. Czeisler // Physiol. Rep. - 2018. - Vol. 6, № 10. - P. 1-15
42. Impact of circadian misalignment on energy metabolism during simulated nightshift work // A.W. McHill [et al.] // Proc. Natl. Acad. Sci. - 2014. - Vol. 111, № 48. - P. 17302-17307
43. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome / A. Englund [et al.] //j. Circadian Rhythms. - 2009. - Vol. 7. - P. 1-9
44. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion / V. Lyssenko [et al.] // Nat Genet. - 2009. - Vol. 41, № 1. - Р. 82-88
45. Wang, J. The orphan nuclear receptor Reverbα regulates circadian expression of plasminogen activator inhibitor type /j. Wang, L. Yin, M.A. Lazar //j. Biol. Chem. - 2006. - Vol. 281, № 45. - P. 33842-33848
46. Hermida, R.C. Chronotherapy with the angiotensin-converting enzyme inhibitor ramipril in essential hypertension: Improved blood pressure control with bedtime dosing / R.C. Hermida, D.E. Ayala // Hypertension. - 2009. - Vol. 54, № 1. - P. 40-46
47. The neurobiology of adaptation to seasons: relevance and correlations in bipolar disorders /j. Maruani [et al.] // Chronobiology International. - 2018. - Vol. 35, № 10. - P. 1335-1353
Review
For citations:
Datieva F.S. CURRERT ASPECTS OF HUMAN CHRONOADAPTATION AND DESASAPTATION. Bashkortostan Medical Journal. 2021;16(6):71-78. (In Russ.)
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