CURRERT ASPECTS OF HUMAN CHRONOADAPTATION AND DESASAPTATION
Abstract
Purpose: to analyze highlight previous and recent literature studies of chronoadaptation problem of the human body by daily and seasonal cycles.Material and methods. The review examines the results of 11 RSCI and 36 PubMed scientific sources by the role of genetically determined structures that regulate the 12-hour, circadian (daily) and circannual (annual) biorhythms of the human body.Results and discussion. The autonomous cellular regulation is caused by self-regulating molecular rhythm generators (oscillators) - circadian genes. They determine the diurnal and seasonal changes in photoperiod changes under the influence of the hypothalamus and pars tuberaslis of the pituitary gland. Cells-organs-organisms of mammals and humans under the influence of the «biological clock» are able to adapt to cyclic processes and stressors, can anticipate them and reform. The disturbance of the coordinated work of the «biological clock» leads to disorders of adaptation, the formation of metabolic disorders, cardiovascular diseases and pathology of the nervous system.Conclusions. Thus, the study of the influence of the laws of adaptation of physiological functions during a certain period of time(day, seasons), with changes in environment (photoperiod), allows a deeper understanding of the etiopathogenesis of diseases, and, therefore, novel therapeutic opportunities for circadian medicine.
About the Author
F. S. Datieva
Институт биомедицинских исследований - филиал ФГБУН ФНЦ Владикавказский научный центр РАН
Russian Federation
Russian Federation
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Review
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Datieva F.S. CURRERT ASPECTS OF HUMAN CHRONOADAPTATION AND DESASAPTATION. Bashkortostan Medical Journal. 2021;16(6):71-78. (In Russ.)
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