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CYTOREDUCTIVE SURGERY WITH HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC). HISTORICAL PERSPECTIVE

Abstract

Purpose: to analyze scientific publications on cytoreductive surgery with intra-abdominal hyperthermic chemotherapy (HIPEC)procedure.Material and methods: foreign and domestic scientific publications.Results and discussion. In the foreign literature, the results of clinical studies evaluating the effectiveness of CRS/HIPEC compared to CRS in patients with peritoneal carcinomatosis of various etiologies have been published, while long-term survival rates were higher in the group who underwent CRS/HIPEC. Despite the fact that there is a sufficient variety of multicenter retrospectivestudies on the treatment of peritoneal carcinomatosis of various etiologies, there is still no clear answer defining indications and contraindications for performing CRS/HIPEC.Conclusions. The treatment of peritoneal carcinomatosis and the evolution of the HIPEC procedure is aimed at optimizing different treatment methods at many levels, including patient selection, preoperative preparation, and determining the safest and most effective chemotherapy regimens. More research is needed in the field of CRS/HIPEC, which will undoubtedly help to further standardize this technique.

About the Authors

M. V. Zabelin
ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России
Russian Federation


A. S. Safonov
ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России; ГБУЗ «Республиканская клиническая больница им. Г.Г. Куватова»
Russian Federation


N. V. Kuznetsov
ГБУЗ «Республиканская клиническая больница им. Г.Г. Куватова»
Russian Federation


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For citations:


Zabelin M.V., Safonov A.S., Kuznetsov N.V. CYTOREDUCTIVE SURGERY WITH HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC). HISTORICAL PERSPECTIVE. Bashkortostan Medical Journal. 2021;16(6):78-87. (In Russ.)

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ISSN 1999-6209 (Print)