FEATURES OF GENE POLYMORPHISM OF THE RENIN-ANGIOTENSIN SYSTEM IN PREMATURE NEWBORNS
Abstract
The aim of the work is to assess the frequency of allelic variants of renin-angiotensin system genes in moderately and extremely premature newborns.Material and methods. A prospective, controlled, single-center, non-randomized study was conducted. Genomic DNA sampleswere studied in newborns with extremely low body weight (ELBW) and gestational age <32 weeks (n=95), moderately premature newborns with gestational age >28 but < 34 weeks (n=105), as well as a population sample of adults (n=100). The following genes were selected for analysis: AGT (rs4762), AGTR1 (rs5186), ACE (Ins\\Del).Results. The distribution of frequencies of alleles and genotypes between the studied groups of individuals was compared.Conclusion. Newborns with both extremely low body weight and moderately premature infants are significantly more likely, unlike the adult population, to be carriers of the allele with the AGT gene.
About the Authors
P. I. Mironov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; ГБУЗ «Республиканский клинический перинатальный центр» МЗ РБ
Russian Federation
Russian Federation
V. R. Amirova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; ГБУЗ «Республиканский клинический перинатальный центр» МЗ РБ
Russian Federation
Russian Federation
A. A. Greshilov
ГБУЗ «Республиканский клинический перинатальный центр» МЗ РБ
Russian Federation
Russian Federation
T. A. Potekhina
ГБУЗ «Республиканский клинический перинатальный центр» МЗ РБ
Russian Federation
Russian Federation
P. F. Rahimova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Mironov P.I., Amirova V.R., Greshilov A.A., Potekhina T.A., Rahimova P.F. FEATURES OF GENE POLYMORPHISM OF THE RENIN-ANGIOTENSIN SYSTEM IN PREMATURE NEWBORNS. Bashkortostan Medical Journal. 2022;17(1):10-14. (In Russ.)
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