PHARMACOLOGICAL SCREENING OF MULTICOMPONENT EXTRACT

Abstract

The purpose of the work is to establish the pharmacological activity of a multicomponent plant extract.Material and methods. The object of the study is an extract obtained from: flowers of Helichrysum arenarium L., fruits of Rosa sp., flowers of Tanacetum vulgare L., leaves of Urtica dioica L., leaves of Mentha piperita L., roots of Glycyrrhiza glabra L., in a ratio of 6:2:2:2:1:1. The extract standardized according to the sum of flavonoids in terms of isosalipurposide - the standard and the luteolin standard. Phenolic compounds are the dominant components in the resulting extract.The choleretic activity of the extract was studied in the previously established dose of 250 mg/kg per os on intact animals and on animals having experimental induced damages of gallbladder and hepatitis model in comparison with the preparation of Allochol. Results and conclusions. The multicomponent extract has a bile effect comparable to that of the comparison preparation. The pharmacotherapeutic effect of the extract is associated with the presence of biologically active phenolic substances. Thus, the multicomponent extract is a promising object for creating a medicinal plant agent of choleretic effect based on it.