SELECTION AND BIOPHARMACEUTICAL STUDY OF AUXILIARY COMPOSITIONS FOR SOME INTRANASAL AND TRANSDERMAL DOSAGE FORMS

An important task in the design of drugs for intranasal use is the choice of the type of dosage form and excipients. We settled on a soft medicinal formgel.Purpose: to select substances from all possible components of gels to create a dosage form with the ginkgo biloba phytocomplex and to study the possibility of creating gel structures that include the synthetic object nifedipine.Material and methods. Methods of molecular modeling and quantum chemistry involving elements of cluster analysis were used for theoretical research. For the confirmation experiment, the method of diffusion into a 2% agar gel with ferric oxide chlorideand the method of equilibrium dialysis through a semipermeable membrane. The selected active model is a well-known phytopreparation, obtained ginkgo biloba extract, as a dosage formgel.Results and discussion. The geometrical and electronic structure of 12 objects (in hydrate form and in vacuum) is characterized.Precision physico-chemical descriptors characterizing the affinity of all components of gels to each other are calculated: hydration heat, ionization potential, specific hydration, heat of formation, dipole moment, energy of the highest occupied molecular orbital, energy of the lower vacant molecular orbital, reactivity and stability indices (chemical rigidity and chemical potential).Conclusions. The theoretical search made it possible to reduce and concentrate the confirmatory experiment, which was traditionally performed using biopharmaceutical techniques in vitro, synthetic object nifedipine.

molecular modeling, dialysis, diffusion, ginkgo biloba, intranasal gel, nifedipine

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