ENDOTHELIAL DYSFUNCTION IN PERIMENOPAUSAL WOMEN

Abstract

Objective: to identify the relationship between the functional state of blood vessels in women of perimenopausal age and the parameters of metabolic and proinflammatory status.Material and methods. The study included 80 women of perimenopausal age, divided into a group with normal endothelial function (n= 36) and a group with endothelial dysfunction (ED) (n= 44). Anamnesis was collected, clinical examination with collection of anthropometric data, assessment of the proinflammatory status, ultrasound examination of the common carotid arterieswere performed. Results. There were no differences in age, prevalence of hypertension, and blood pressure. A significant negative correlation was revealed between the endothelium-dependent vasodilation of the right brachial artery and the body mass index (ρ= -0.25), the ratio of waist circumference to hip circumference (ρ= -0.26), the lumen of the right (ρ= -0.40) and left (pρ= -0.36) common carotid artery, C-reactive protein (ρ= -0.22). Kramer's coefficient V between the presence of ED and obesity - 0.39, p <0.05; between the presence of ED and menopause - 0.40, p<0.001.Conclusion. ED has close correlations with anthropometric data, obesity, menopausal and proinflammatory status in perimenopausal women.