DIAGNOSTIC SIGNIFICANCE OF OPTICAL MARKERS IN PATIENTS WITH NON-MUSCLE-INVASIVE BLADDER CANCER

Abstract

The aim of the present study is to determine the optical markers of non-muscle-invasive bladder cancer using the method ofRaman spectroscopy.Material and methods. Raman spectroscopic study of postoperative material was carried out in 120 patients with a diagnosis of non-muscle-invasive cancer. The mean age of the patients was 63 years. In total, about 3000 spectrograms were obtained. Results and discussion. According to the results of the study, the Raman spectra of samples of non-muscle-invasive bladder cancer have characteristic features in the form of a set of peaks in the range from 502 to 3460 cm-1. The morphospectroscopic profile of non-muscle-invasive bladder cancer is characterized by the presence of Raman peaks associated with the hydroxyl radical (502 to 730 cm-1),725 cm-1 (adenine CH group), phenylalanine (1031 cm-1), C-NH2 bond in molecules of adenine, guanine and cytosine (850 cm-1, 1250 cm-1), β-D-glucopyranose (989 cm-1), α-helical conformation, C = C-linkages of lipids (1450-1660 cm-1).Conclusion. The data obtained using the Raman spectroscopy method have additional diagnostic significance and can be used to select further treatment tactics.