APPLICATION OF CLUSTER ANALYSIS IN THE FORMATION OF PRIMARY OPEN-ANGLE GLAUCOMA PHENOTYPES
Abstract
The purpose is to study the effectiveness of using the hierarchical cluster analysis for the formation of primary open-angle glaucoma phenotypes.Material and methods. Cluster analysis to process a standardized set of clinical and genetic parameters of 348 patients (696 eyes) aged 45 to 87 (mean 61.28±10.13) years with various stages of primary open-angle glaucoma (POAG). was used.Results. Based on the results of multivariate analysis, parameters were identified that play an important role in dividing thesample of patients with POAG into clinical phenotypes. In order to determine the possible phenotypes of patients, clustering was carried out according to the Ward method with the tree diagram formation and the definition of four clusters. Using the McQueen k-means method the structures of clusters (phenotypes) of POAG patients were obtained with a high percentage (96.8%) of the correctness of the initial observations grouping.Conclusions. 1. The high efficiency of hierarchical cluster analysis in the formation of POAG phenotypes has been shown.2. Based on the study of qualitative and quantitative anamnestic, clinical and functional, morphometric and genetic parameters of patients, four clinical phenotypes of primary open-angle glaucoma were formed.
About the Authors
A. Sh. Zagidullina
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
B. M. Aznabaev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
R. Kh. Zulkarneev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. I. Arslanova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; ГБУЗ РБ «Городская клиническая больница №8»
Russian Federation
Russian Federation
S. R. Avkhadeeva
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Zagidullina A.Sh., Aznabaev B.M., Zulkarneev R.Kh., Arslanova A.I., Avkhadeeva S.R. APPLICATION OF CLUSTER ANALYSIS IN THE FORMATION OF PRIMARY OPEN-ANGLE GLAUCOMA PHENOTYPES. Bashkortostan Medical Journal. 2022;17(4):5-9. (In Russ.)
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