STUDY OF BIOCHEMICAL PARAMETERS IN PATIENTS WITH CHRONIC HEPATITIS C IN THE DYNAMICS OF TREATMENT WITH DIRECT-ACTING DRUGS

Purpose is to study the viral load and characteristics of some biochemical parameters in the dynamics of treatment with directacting antiviral (DAA) drugs in patients with chronic hepatitis C of varying severity.Material and methods. The study was conducted in the laboratory of the Republican center for prevention and control of AIDSand infectious diseases, the Republic of Bashkortostan, Ufa. Under observation were 40 patients with chronic hepatitis C, divided into two groups according to the severity of the disease. To assess the severity of liver fibrosis, the method of fibroelastometry was used with an assessment of its degree according to the METAVIR scale. In the study, a number of important biochemical parameters reflecting the functional state of the liver were evaluated at three stages of observation.Results and discussion. The dynamics of viral load in the blood in hepatitis C corresponded to moderate viremia in the first group and high viremia in the second group of patients with chronic hepatitis C at the first stage (before treatment). At the subsequent stages of monitoring the effectiveness of therapy, HCV RNA was not detected in the first group, in the second group it was detected in isolated cases. According to the results of liver fibroelastometry, severe fibrosis (F3 on the METAVIR scale) was detected in the first group and liver cirrhosis (F4) - in the second group of patients.Screening analysis used some biochemical indicators: ALT, AST, GGT, cholinesterase, alkaline phosphatase, total protein, bilirubin and blood glucose.By the end of antiviral therapy in the first group of patients, all biochemical parameters reached normal values, and in the groupof patients with liver cirrhosis, most of the analyses had only a tendency to recovery.Conclusions. To assess the effectiveness of antiviral therapy of DAAs in patients with chronic hepatitis C with severe fibrosis and cirrhosis of the liver, the viral load and biochemical blood parameters by control stages were used. An immediate virological response was achieved in 100% of patients of the first group with liver fibrosis and in 67,7% of patients of the second group with liver cirrhosis.

chronic hepatitis C, antiviral therapy, direct-acting drugs, blood biochemical parameters