GRANULES BASED ON NATURAL MEDICAL CLAY

Abstract

Recent studies have shown the high efficiency of using enterosorbents based on natural mineral raw materials.The aim of the work is to develop the composition and technology for obtaining enterosorbent granules based on a natural mineral complex (NMC) - Kimmeridgian (blue) healing clay «Undorovskаyа».Material and methods. The authors used physicochemical, technological, biopharmaceutical research methods.Results. A technological method has been developed that makes it possible to obtain granules that meet the requirements of current regulatory documentation. The adsorptive activity of NMC granules - «Undorovskaya» healing clay in relation to toxicants of medium molecular weight - solutions of medicinal substances of various concentrations, was studied in order to be able to use this enterosorbent in case of moderate poisoning. In vitro experiments proved the lack of influence of the pH of the medium on the adsorption activity of the granules. The storage stability was studied and the experimental shelf life of the granules was determined.