THE RISK FACTORS OF CARDIOVASCULAR PATHOLOGY AND THE CARDIOTOXITY OF THERAPY OF NON-SMALL- CELL LUNG CANCER

Abstract

Cardiovascular complications caused by the use of important vital medicines for the treatment of lung cancer attract researchers (oncologists and cardiologists) to study the manifestations of cardiovascular diseases (CVD) in the treatment of oncopathology. The review presents data suggesting that risk factors associated with CVD are also associated with an increase in morbidity and mortality from lung cancer. It is emphasized that smoking is the main cause of lung cancer and is also a risk factor of the development of CVD. The issues of cardiotoxicity caused by chemotherapy as the main cause of cardiovascular morbidity in cancer patients are considered. The epidemiology of cardiotoxicity in the use of various groups of chemotherapeutic drugs (alkylating agents, antimetabolites, mitosis inhibitors, topoisomerase II inhibitors) is presented. The possible mechanisms of the effect of chemotherapy on the cardiovascular system are analyzed.