LONG-TERM RESULTS OF SURGICAL TREATMENT OF GLAUCOMA DEPENDING ON PREVIOUS DRUG THERAPY
Abstract
The aim is to study the effect of long-term treatment of primary open-angle glaucoma (POAG) on the success of glaucoma surgery after 8-years time.
Material and methods. The study included patients with POAG who had been using antihypertensive treatment for a long time and who had been operated on for glaucoma. Patients were divided into 5 groups according to the antihypertensive drugs used: group 1 – prostaglandin analogues (PA); group 2 –beta blockers (BB); group 3 – fixed combinations (FC) of PA and BB; group 4 – FC carbonic anhydrase inhibitors and BB; group 5 – maximum drug glaucoma therapy. Stabilization of intraocular pressure (IOP) and mean deviation index (MD) were assessed 8 years after the surgery.
Results. Intraocular pressure (IOP) was stabilized in 31 patients (77.5%) over an 8-year period. Statistically significant differences in this indicator were found in groups of patients, who used PAs for a long time in monotherapy and in the form of fixed combinations. Progression of the MD index according to computer perimetry data was noted in all study groups during the assessed period, but the differences in the indicators were not statistically significant.
Conclusion. A stable hypotensive effect of antiglaucomatous operations (AGO) was achieved in the group of patients who used PA before surgery. Long-term use of antihypertensive drugs leads to failure of AGO in 32.1% of cases, expressed in the development of active scarring of the filtration zone and vascularization of the surgical area.
About the Authors
A. A. Gusarevich
ЧУЗ «Клиническая больница «РЖД-Медицина»;
ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
M. M. Pupуsheva
ЧУЗ «Клиническая больница «РЖД-Медицина»
Russian Federation
Russian Federation
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Review
For citations:
Gusarevich A.A., Pupуsheva M.M. LONG-TERM RESULTS OF SURGICAL TREATMENT OF GLAUCOMA DEPENDING ON PREVIOUS DRUG THERAPY. Bashkortostan Medical Journal. 2024;19(2):55-59. (In Russ.)
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