Objective: to evaluate the efficacy and safety of surgical myocardial revascularization in the early period after stenting of clinical-dependent artery (up to 90 days) with drug-coated sirolimus of the 3rd generation in patients with acute coronary syndrome without ST-segment elevation and multivessel lesion.We have conducted a retrospective analysis of the results of 2 year observation of staged treatment of patients with acute coronary syndrome without ST-segment elevation and multivessel coronary artery disease who underwent stenting clinical dependent artery for emergency indications, and then in a period of up to 90 days underwent coronary artery bypass grafting. Statistical analysisof quantitative indicators was made by calculation of mean value and standard deviation. Qualitative indicators are represented byfrequency ratio in percent. Efficacy and safety assessment was carried out according to the criteria of «non-inferiority» in comparison with the literature data of myocardial revascularization by stenting. Differences were evaluated by assessment of the value of two-sided 95% confidence interval of odds of the obtained negative events proceeding from “non-inferiority” design.Surgical myocardial revascularization in the early stages after stenting of the clinically dependent artery in patients with acute coronary syndrome without ST-segment elevation and multivessel lesion is equivalent in efficacy and safety to percutaneous coronary intervention.

The study aimed to analyze the effectiveness of circular sympathetic denervation of pulmonary trunk and arteries mouths in patients with mitral valve dysfunction, complicated by atrial fibrillation and high pulmonary hypertension, as well as to reveal the influence on the change of quality of life of these patients. We have analyzed the results of surgical treatment of 202 patients with mitral defect accompanied by atrial fibrillation and high pulmonary hypertension (more than 40 mm Hg). Operative treatment in these patients included surgical correction of mitral valve defect - prosthesis or reconstruction of native valve - the first group of patients (n-62). Surgical correction of atrial fibrillation and pulmonary hypertension in this group of patients was not performed. Patients of the second group (n-89) underwent correction of mitral defect with the subsequent biatrial radiofrequency ablation using Maze IV scheme with the application of Atri Cure bipolar ablator under transmularity control. A complex intervention including elimination of mitral valve defect, Maze IV procedure and circular denervation of pulmonary trunk and pulmonary arteries mouths (Pulmonary Artery Denervation - PADN) was conducted on the patients of the third group (n-51).PADN is an effective and safe method of surgical treatment for high secondary pulmonary hypertension. It promotes b ack remodeling of heart cavities, in particular left atrium (p-0.01), normalization of pulmonary hypertension and reduction of heart failure (p=0.023).Complex surgical treatment of patients with mitral defect, atrial fibrillation and high pulmonary hypertension significantly improves the results of Maze IV procedure by restoration and creation of sinus rhythm in 3-month’s time after surgery (p=0.008).

In accordance with III universal definition of myocardial infarction currently it is recommended to point out five types of myocardial infarction depending on a medical case development mechanism. This article provides clinical and anatomical analysis of239 cases of different types of myocardial infarction, features of its diagnosis, frequency of development. Authors note that while myocardial infarction of first and second types is more common among senior people, myocardial infarction of fourth and fifth typeshas a clear increasing tendency among men due to cardiovascular surgical activity.

The aim of the study was to evaluate the effect of localization of an intrauterine hematoma on the course of pregnancy and its outcome.A prospective observational study was conducted that included 78 women with endometrial hematoma, 64 of whom had subchorial hematoma and 14 subamnial. The comparison was carried out according to the main demographic characteristics, characteristics of the course of pregnancy, obstetric and neonatal outcomes.The analysis showed that it was equally common in the group of women with subchorial and subchorionic hematoma. The size of hematomas in the group of women with terminated pregnancy was significantly larger compared with those who managed to maintain the pregnancy to a period of more than 22 weeks. At the same time, there were no significant differences in the incidence of gestational complications after 22 weeks among women with subchorial and subamniotic hematomas.According to the results of the study, the frequency of complications in the group of women with subamnial hematomas is comparable to the similar indicators in the group with subchorional hematomas. The volume of subamniotic hematomas was greater, but this did not affect the incidence of adverse outcome during intergroup comparison.

The aim of the study was to determine the prevalence of different types of human papillomavirus (HPV) among Ufa residents using the polymerase chain reaction.The work aimed to determine the prevalence rate of different types of human papillomavirus (HPV) among female population of Ufa using polymerase chain reaction.The most common types of viruses in the group of women aged 20-24, were 16, 53 and 51. Among women aged 25-29, 16, 56 and 44 types predominated. Viruses 16,44, 56 and 53 prevailed in the group of 30-34 years. In patients of 34-39 years old, virus types 16, 44, 33 were mainly observed. HPV 16, 51, 33, 56, and 73 prevailed in the 40 -44 years group. Women aged 45-49 years were mainly infected with viruses 16, 52, 56, 73. The most common types of HPV in all groups were 16, 56 and 44.Papillomavirus types 16, 53, 56, 44, 51, 52, 33 and 73 prevail in the female population of Ufa. This result shows that the geno-typic diversity of HPV in the capital of Bashkortostan is similar to various Asian countries. These data should be considered when developing screening and prevention programs.

The article discusses various approaches to assessing the psychological state of students in the educational process of the University. The research was conducted at the Bashkir State Medical University during 2017/2018 and 2018/2019 academic years covering first-year students of the Medical, Pediatric, Dental Faculties as well as of the Faculty of Preventive Medicine. The study used Spilberg-Khanin scale to assess reactive and personal anxiety. The investigation revealed the level of anxiety of students as a property of personality and as a condition associated with the current educational situation.The paper also describes the features of pedagogical approach to work with the students having the greatest indicators on levelof anxiety at departments of human sciences. The conclusion is made about the need to develop stress resistance and recommendations for teachers to work with highly anxious students are suggested.

Nowadays, vaccination is a very urgent problem in connection with numerous controlled infections episodes throughout the world and increasing tendency of parents to refuse vaccination. The research was conducted to study the attitude of parents t o preventive vaccination of children. The study included questionnaire survey of 400 parents aged from 20 to 50 years old. In the course of the work, it was found out that the main part of the parents have a positive attitude towards vaccination (206 people - 51%), but there are those who treat vaccine prevention with distrust and require separate attention from health workers in carrying out sanitary and health communication. In 49,8% of cases parents are in fear of vaccination adverse effects. It is connected with the lack of knowledge about vaccines composition, safety of adjuvants and stabilizers, which are added during manufacturing, as well as mode of administration. It is necessary to raise awareness of parents, to find the ways to explain the base of preventive immuniza tion to boost the immune coverage of population and to bring up the healthy generation of our country.

Nowadays, there is an undoubted link between the skeleton and adipose tissue at various functional levels; however, there is no complete information about skeletal morphogenesis in obesity at this time. The aim of the research was to establish the characteristics of the chemical and macroelemental composition of bones in rats of different ages with alimentary obesity. The experimen t was carried out on male rats of the two groups: group 1 - control, group 2 - rats receiving 6 weeks palm oil in dose of 30 g/day/kg. The periods of the experiment were 1, 10, 30 and 60 days after 6 weeks from the start of palm oil intake. The chemical composition of the bones was determined by weight and spectrophotometry methods. The use of palm oil in dose of 30 g/day/kg is accompanied b y an increase in the content of water, sodium and potassium, and a decrease in the content of organic and mineral substances, calcium and the ratio of calcium/phosphorus which increases with the duration of use of palm oil. These changes are most pronounced in adult and elderly animals, and to the least extent in juvenile rats.

The aim of the study was to assess the methods of death of human ejaculatory sperm by methods of apoptosis and necrosis in vitro.The ejaculates of 40 fertile men aged 22 to 38 years were studied. Sperms were isolated from ejaculate samples, washed fromthe seminal plasma with phosphate-salt buffer. Motility and viability of germ cells, including in the presence of apoptosis marker (externalization of phosphatidylserine, detected by binding to Annexin-V) were investigated in freshly isolated sperm and sperm after 4 and 24 hours of incubation in vitro at 37°C.After 4 hours of incubation in vitro no significant changes in sperm parameters were found, but after 24 hours of incubation there was a decrease in motility and viability of germ cells. However, these changes were not accompanied by any increase in the level of gametes with the marker of apoptotic process. The study found that ejaculatory sperm of a healthy person does not trigger the process of apoptosis at least in vitro.

The aim of the study was to determine the spectrum of drug resistance of Hafnia alvei clinical strains to the most widespread antibacterial drugs. The work evaluated sensitivity of bacteriophages to Hafnia alvei strains. Antibiotic resistance was established by disk diffusion test, where disks were saturated with 23 widely used antibiotics: penicillin, ampicillin, ampicillin/sulbactam, oxacillin, carbenecillin, lincomycin, kanamycin, erythromycin, rifampicin, streptomycin, gentamycin, tobramycin, norfloxacin, gemifloxacin, moxifloxacin, tetracycline, axetine cefuroxime, ceftazidime, cefepime, chloromycetin, nystatin, and with nitrofurans: nitrofurantoin, furaginum on 80 Hafnia alvei clinical strains, taken from patients with gastro-intestinal, urological and pyoinflammatory diseases. Clinical material was obtained from bacteriological laboratories of the Republic of Bashkortostan. Bacteriophage was received by a common method from laboratory clinical wastes. To determine sensitivity of bacteriophage to Hafnia alvei clinical strains spot-test was applied. Analysis of the results showed that among Hafnia alvei clinical strains 7.5% (6 units) were resistant to cefepime, 11% (9 units) to ceftazidime, 15% (12 units) - to gemifloxacin, 13.7% (11 units) - to moxifloxacin and were equally resistant to ampicillin, ampicillin/sulbactam, axetine cefuroxime, cefolatin - 90±3.75. Bacteriophage can lyze 65 cultures (81%) from80 Hafnia alvei clinical strains, including antibiotic resistant - 60 strains (75%). Summering the results, one may conclude, that ceftazidime, cefepime, gemifloxacin, moxifloxacin and bacteriophage can be used as treatment and preventive drugs during antibacterial therapy of infections caused by Hafnia alvei bacteria, including antibiotic resistant strains.

The development of methods for the quantitative determination of active pharmaceutical substances planned to be included in the regulatory documentation requires validation activities. This article presents the results of the validation of a spectrophotometric method for the quantitative determination of birch leaves polysaccharides (PSBl) with lipid-lowering activity. The proposed method is distinguished by specificity, linearity (0.04-0.12 mg / ml), correctness in the range of contents of 75-120% (2.8-4.1%) and precision under repeatability conditions (0.25-0.44 %) and reproducibility (0.44-0.89%). Thus, the suitability of the technique for quantitative spectrophotometric determination of PSBl for inclusion in the regulatory documentation for a substance being developed is shown.

This article presents the results of a study of the prevalence of arterial hypertension among individuals with a reliably established diagnosis of pheochromocytoma, which is a benign, hormonally active neoplasm of the adrenal medulla or chromaffin outside the adrenal tissue. The results of instrumental methods of examination and treatment of patients with a diagnosis of pheochromocytoma, adrenal and outside adrenal localization with concomitant arterial hypertension and changes in laboratory parameters in the form of hypokalemia, elevated plasma aldosterone and reduced renin activity were studied. In total, 57 people took part in the study, of which 26 were men and 31 women aged from 21 to 54 years old. The study revealed that outside the adrenal localizati on of the neoplasm was accompanied by sustained hypertension, resistant to antihypertensive drugs. With the adrenal location of the pheochromocytoma, transient crises with associated autonomic disorders were more often observed. The radical surgical treatment of pheochromocytoma has led to a persistent normalization of blood pressure in most patients.

This article presents the experience of surgical treatment of patients with urogenital endometriosis using laparoscopic and robotassisted methods in the Clinic of Bashkir State Medical University in 2018. There were 17 surgical interventions for infiltrative forms of endometriosis of different localization involving the urinary tract. Gynecological and somatic anamnesis was studied in detail in these patients. We compared different methods of surgical treatment. It was found that the size of the infiltrate more than 3 cm is a diagnostic sign of the development of urogenital endometriosis. The main stage of treatment of these patients is a su rgical method using modern mini-invasive approaches. The method of choice is the use of Da Vinci platform, the advantage of which is the greatest safety and less blood loss. When using robot-assisted surgery, it is possible to perform more complex manipulations and the duration of rehabilitation is reduced. Robot-assisted intervention is an ideal access for urogenital endometriosis and the ability to perform nerve-saving operations.

Urinary tract infections are the most common bacterial infections in women, especially during pregnancy. One of the most frequently observed urinary tract infections is asymptomatic bacteriuria (АB), which is characterized by mild clinical symptoms, but can lead to severe complications of pregnancy, with the development of sepsis in a short period of time and fetal death. This review is dedicated to ensure the rational use of antibacterial agents and to assist clinicians in determining the indications and conditions for antibiotic therapy in pregnant women with АB. The review includes publications devoted to this problem from PubMed, eLibrary databases. Prescribing medications during pregnancy should be reasonable, taking into account the state of the mother and the fetus and the benefit-risk relationship. Timely diagnosis and adequate antibiotic therapy for pregnant women with АB will reduce the incidence of pregnancy complications and improve perinatal outcomes.

The review presents current data on various aspects of endometrial hyperplastic processes. The etiopathogenetic mechanisms of endometrial hyperplasia in women of reproductive age are systematized. Molecular genetic, proliferative-apoptotic mechanisms for the development of pathology are shown, data on the features of expression of progesterone receptors and estrogens, the role of cytokines, hormone-metabolic processes in women with obesity, the influence of inflammatory processes of the genitals, and pathological neoangiogenesis, impaired immune status are presented.

A review of the literature data on the methods, effectiveness, and safety of the proposed (continuous) local injection of anesthetics in the postoperative period after abdominal operations has been carried out. There are at least 4 methods of this technique: with the installation of catheters in the subcutaneous tissue, in the musculo-fascial sheath, in the preperitoneal and abdominal cavity in the zone of greatest dissection. Most authors of the analyzed publications consider this technique to be an effective and safe method of postoperative pain relief and an alternative to epidural anesthesia or medical methods of pain relief (opioid).

The history of embalming and preservation of autopsy material has quite an important practical value. The issues of development of modern, safe for the department staff and students methods of restoration and conservation of anatomical preparations require increased attention from the faculty and management of universities. Nowadays, there are a large number of methods for preserving autopsy material, which are conventionally divided into physical and chemical. The founders of the embalming of the bodies of the dead are considered to be ancient Egyptians, whose mummies have been preserved for over 2,000 years. The body of the great surgeon Nikolai Ivanovich Pirogov, who was interested in the subject of embalming, during his life, remains to this day. Today, the embalming and preservation technique of the autopsy material has been improved and developed. The newest method of plastination and polymer embalming is actively gaining popularity and has been introduced into the educational process.

The article is devoted to professors of Lomonosov Moscow State University, in different years headed the Department of Anatomy at the Medical Faculty of the University and made a significant contribution to its formation. The paper covers research and teaching activities of the Heads of the Department, their contribution to the development of anatomy, especially the approach to the teaching of the subject. Initially, the Department of Anatomy was headed by invited foreign professors, who were replaced by talented domestic scientists who created one of the strongest departments of anatomy in the world. In addition, the training, which initially took place exclusively in Latin, is replaced by Russian. A significant contribution was made by the first Russian Professor of the Department Semyon Gerasimovich Zibelin. The article touches upon the history of translation of atlases, tables and textbooks into Russian and, last but not least, the latest medical works. The article describes the formation of the collection of the An atomical Museum and its development on the basis of the Department, since the presence of anatomical preparations is necessary for the study of anatomy. The article is based on the memories of students and colleagues.