The aim of the research was to study the impact of COVID-19 on cardiovascular endpoints development within 1 year in hospitalized patients with acute myocardial infarction (MI) with ST segment elevation (STEMI), in which this viral disease was detected during the hospital period.

Material and methods. The case histories of 179 patients who were admitted to the city clinical hospital (CCH) No. 21 in Ufa from January 2020 to December 2021 to the cardiology department were studied. The patients with STEMI were divided into 2 groups. The experimental group of patients (MI-COVID) were diagnosed with COVID-19 during hospitalization (n=20), in control group (MI-nonCOVID) the infection was not detected (n=159). The presence of COVID-19 infection was confirmed using IgM studies, as well as PCR swabs from the throat and nasopharynx. After 1 year of follow-up, cardiovascular endpoints were studied using the PROMED electronic medical data storage system.

Results. Our analysis showed a tendency towards significant unfavorable course and prognosis, as well as an increase in cardiovascular mortality in STEMI patients with COVID-19 infection in comparison with patients with STEMI without this infection.

The objective of the research. To assess the prognostic value of the severity of the inflammatory response and the level of key coagulogram markers in patients with severe COVID-19.

Material of the research. We analyzed 110 case histories of patients aged 20 to 95 years with a severe form of coronavirus infection. The patients were divided into 2 groups: the first group consisted of 56 patients who recovered, the second group consisted of 54 patients whose disease had lethal outcome. The severity of inflammatory reaction was assessed by the number of leukocytes, peripheral blood neutrophils, C-reactive protein (CRP) and ferritin. Hemostasis system was assessed by blood platelet count, D-dimer level, prothrombin time and activated partial thromboplastin time (APTT). Analysis of the studied parameters was performed on the day of hospitalization and before the disease outcome.

Results. It was found that on the day of hospitalization in the group of deceased patients the number of neutrophils in the blood was significantly higher than in the group of survivors. There were no statistically significant differences in the values of CRP and ferritin. Prothrombin time and D-dimer values differed on the day of hospitalization: median D-dimer, in particular, in the deceased group was 3 times higher than in the comparison group.
Analysis of inflammatory markers at the end of the disease showed that median values of the key inflammatory markers - leukocytes, neutrophils and CRP - in the group of deceased patients were significantly higher than in the comparison group. The most notable difference was in the level of CRP, the median of which was 16.7 times higher among the deceased compared to the survivors. The mean values of hemostasis indices in the group of the deceased were the highest. The most significant difference was demonstrated by D-dimer, the median of which was 7.8 times higher in the deceased than in the comparison group (p<0.001). D-dimer level above 1000 ng/ml is associated with a high risk of mortality (p<0.05).

Conclusions. The studies showed that in the group of deceased patients a pronounced inflammatory activity of the blood remained throughout the disease, which created conditions for long-term endothelial dysfunction and implementation of the prothrombotic potential.

The objective of the study was to assess the risks of developing wound infection, taking into account the pharmacokinetics of ceftriaxone used as a means of perioperative antibiotic prophylaxis during breast surgery.

Material and methods. 53 patients who had undergone surgery for breast cancer were examined. Verification of ceftriaxone in biological media was performed by capillary electrophoresis (KAPEL-105M; Lumex, St. Petersburg). Laser-Doppler flowmetry (LAKK-02; Russia) was used for microcirculation assessment.

Results and discussion. On the first day after surgery, the wound area had increased microcirculation by rising the maximum amplitude of the endothelial (p=0.049) and myogenic (p=0.037) control factors. On this background, an hour after the administration of ceftriaxone, its maximum content was in the muscle tissue (50,5±9,52 μg/0.1 g). A minimum of the drug was detected in the subcutaneous tissue, which determined the risk of developing a wound infection there.

Conclusion. After a breast cancer surgery, the local status of nutritive channel provides a stable concentration of ceftriaxone in the vulnar zone administered for perioperative antibiotic prophylaxis. The resulting complications (infiltrate, "seroma") have minimal clinical significance.

The article presents the experience of the Department of Vascular Surgery of the Emergency Clinical Hospital in Ufa in secondary prevention of recurrence of acute cerebrovascular accident (ACVA) in patients in the acute period of ischemic stroke. According to the «Perioperative management of patients with concomitant pathology of the central nervous system» clinical guidelines of the Federation of Anesthesiologists and Resuscitators, it is not recommended to perform planned surgical interventions earlier than 9 months after acute cerebrovascular accident. However, in the «National Clinical Guidelines for the Management of Patients with Brachycephalic Artery Disease», the interventions on the carotid arteries are recommended within 14 days after an ACVA of an ischemic type.

Material and methods. For the period of 2021-2022 in the Department of Vascular Surgery of the Emergency Clinical Hospital in Ufa, 443 patients with carotid artery stenosis were treated. Of this number, 350 patients underwent "open" interventions. All patients who underwent "open" interventions were divided into 2 groups: group 1 - 152 patients in the acute period of ischemic stroke, transferred from the "stroke" departments on the 10th–12th day and operated no later than 14 days after an ACVA; group 2 - the remaining patients.

Conclusion. The analysis of postoperative complications showed the effectiveness and safety of "open" surgical interventions in patients within the first 14 days after the ACVA. The complication rate and mortality do not exceed those in patients outside the acute period of stroke.

Objective. To assess the frequency of development of true aneurysms of native permanent vascular access and to identify the causes leading to their occurrence.

Material and methods. A survey of 219 patients undergoing programmed hemodialysis was conducted. Group I (195 people) consisted of patients without permanent vascular access aneurysms, group II (23 people) patients with a diameter of permanent vascular access more than 20 mm.

Results. The presence of catheterizations of homolateral central veins in the anamnesis in patients was statistically insignificant (p=0,152). There were also no statistical differences depending on gender and age. In 91.3% of group II patients, the volumetric blood flow exceeded 1 l/min, while in 26.1% this indicator exceeded 2 l/min. Abnormal bypass-cardiac fraction was registered in 82.6% of patients.

Conclusions. True aneurysms of native permanent vascular access were detected in 11.8% of patients. A statistically significant relationship between the occurrence of aneurysms of permanent vascular access and the duration of functioning of this access was revealed. The presence in most patients of a high flow along the fistula and an abnormal bypass-cardiac fraction (82,6%) indicates the need for dynamic monitoring to prevent the development of congestive heart failure.

The objective of this study was to study the variant anatomy and topography of the pudendal nerve in mature men according to magnetic resonance imaging (MRI).

Material and methods. The present study included 140 patients aged 21 to 59 years of first and second periods of adulthood. The inclusion criteria for patients in the study were: the absence of active complaints from the genitourinary system and pathological processes in the pelvic cavity according to the MRI study. MRIs of the small pelvis for analyzing the variant anatomy and topography of the pudendal nerve were obtained using Siemens Magnetom Essenza 1.5 T (Siemens, Germany) and Phillips Achieva 1.5 T (Phillips, the Netherlands) MRI devices in three planes without the administration of a contrast agent.

Results. The study of the nature of the pudendal nerve branching and the types of relationship of the pudendal nerve and its branches to the sacrospinous ligament showed the following results: the most common type was type I (single-barreled nature of the branching of the nerve; the pudendal nerve passes under the sacrospinous ligament), which was detected in 79 (56, 4%) patients, the least common was type V (three-barreled nature of the branching of the nerve; the pudendal nerve passes under the sacrospinous ligament), identified in 12 (8.5%) respondents. The sources of formation of the pudendal nerve in 72 (51.5%) cases were the roots of S2, S3 and S4, in 59 (42.1%) patients the pudendal nerve was formed from S2 and S4 roots, and in 9 (6.4%) cases the pudendal nerve originated from S3 and S4 roots. When comparing the average values of the diameters of the main trunks of the pudendal nerve of the patients of the first and second periods of adulthood, we noted significant differences (4.65±1.15 mm and 3.88±0.94 mm, respectively, p=0.029). The comparison of the average lengths of the pudendal nerve trunks of patients of the first and second periods of adulthood showed no significant differences (p=1.0). With pronounced filling of the rectum and the bladder, there is a maximum «pressing» of the main trunk of the pudendal nerve to the obturator internus muscle and ischial spine.

Conclusion. An MRI study of the pelvic organs in mature men with T2-weighted images data allows a detailed study of the variant anatomy and topography of the pudendal nerve from the origins of its formation to division into terminal branches. This imaging method is distinguished by the highest intertissue contrast, high spatial resolution and the ability to obtain sections in any plane.

The purpose of the study. To study the cross-sectional area of the tympanic segment of the facial canal near the second genu, as well as to measure the angle of the second genu in people of different ages with the determination of the gender characteristics of these parameters.

Material and methods. 133 head tomograms of people of different ages were studied. The tomograms were divided into age groups: 7-12 years old, 13-16 years old, 17-21 years old, 22-35 years old, 36-60 years old and 61-74 years old. In each group, male and female subgroups were distinguished.

Results and discussion. Comparing separate age groups of men and women, it was found that significant differences are observed in women. So, when comparing the age groups of 22-35 years and 36-60 years, significant differences were noted in the size of the angle of the second genu both on the left (0.001) and on the right (0.008). Comparison of groups aged 22-35 years and 61-74 years old revealed the reliability of the indicators of the cross-sectional area on the right (0.008); 13-16 years old and 36-60 years old – the angle of the second genu on the left (0.009); 17-21 years old and 36-60 years old – indicators of the angle of the second genu on the right (0.049) and the cross-sectional area on the left (0.014); 17-21 years and 36-60 years – cross-sectional area on the left (0.012), 36-60 years and 61-74 years of the second genu angle on the right (0.003).

Conclusion. As a result of the above, it can be concluded that the cross-sectional area of the tympanic segment increases from the age of 7 and becomes the largest by 35 years of age, then gradually decreases. A similar picture was observed when comparing the angle of the second genu in different age groups. Considering the gender differences in both parameters, we found that significant differences are observed in women, both on the right and on the left.

The aim is to obtain new data on the features of the anatomy and topography of the sensitive ganglia of the spinal nerves at the 18-22 weeks fetuses of prenatal ontogenesis.

Material and methods. The research was carried out on the sectional material of 40 human fetuses of both genders of the 18–22 weeks development obtained as a result of abortion on social indications from fetal collection of the Department. The methods of macro-microscopic preparation, N.I. Pirogov technique of variously-planed sections, histotopographic method with van Gieson’s staining were used in the study.

Results. It was revealed that the sensitive ganglia of the spinal cord were fully formed at 18-22 weeks of development. The cervical ganglia are located extraforaminally, have the oval shape and a horizontal position. The size of the ganglia increases from C₁ to C₈, the first cervical ganglion differs from the rest in shape and size. Thoracic sensitive ganglia are located intraforaminally, have a round shape. The first thoracic ganglion is similar in shape and size to the cervical ganglia. The lumbar ganglia are located inside the vertebral canal, have an elongated oval shape and increase from L₁ to L₅. The sacral and coccygeal ganglia are similar in shape and location to the lumbar ganglia, but differ by small size.

Conclusions. The obtained data on the anatomy and topography of fetus sensitive ganglia at 18-22 weeks of development can be useful for ultrasound diagnostics doctors, neonatologists and fetal surgeons.

Aim of the work is to study the local features of pleural structure as a system that provides circulation of serous fluid.

Material and methods. The article presents the results of the study of various topographic zones of the parietal and visceral pleura, diaphragmatic peritoneum. The original method of impregnation of total film preparations with silver nitrate followed by stereomicroscopy in reflected light was used (patent No. 2413943). The material was obtained from 29 corpses of mature persons.

Results. The conducted studies revealed topographic zones of the parietal pleura with the maximum concentration of drainage holes – the diaphragmatic pleura in the area of its tendon center and the costal pleura in the projection of intercostal muscles. These primary links in the pleural fluid drainage system are characterized by significant variability both in size (from 2-6 microns to several millimeters in diameter) and in shape. The internal structures of the holes in the form of trabecules and septal structures are described. They stabilize the lumen of drainage paths and ensure the circulation of serous fluid. Morphological data confirming the functional interaction between the microcirculation pathways of the diaphragmatic pleura and peritoneum were obtained.

Conclusion. The parietal leaf of pleura in its costal and diaphragmatic parts has specialized loci of a high degree of fenestration. Drainage holes as a structural and functional module of these pleural loci are the main way of reabsorption of serous fluid.

Objective of the research. Development of a method for standardization of the leaves of common pomegranate (Punica gran-atum L.) according to the content of flavonoids.

Material and methods. The object of the study was the leaves of the common pomegranate (Punica granatum L.) harvested during its flowering in 2020-2022 on the territory of the Republic of Azerbaijan.
The spectral analysis of alcohol extracts was carried out in the range from 220 to 450 nm in order to establish the dominant flavonoid. For the quantitative determination of flavonoids, the method of differential spectrophotometry in the UV and visible regions was used.

Results. In the course of the development of the method, it was established that the optimal parameters for the extraction of flavonoids from the Punica granatum leaves are: the extractant - ethyl alcohol 95%, the correspondence of the mass of raw materials and the amount of extractant - 1:100, the multiplicity of extraction - single, the optimal particle size of raw materials - 1 mm, the extraction time - 30 minutes, the concentration of aluminium chloride solution of 1% in ethyl alcohol 70%, the amount of the added complexing agent - 5 ml, the reaction time with the complexing agent - 40 minutes.

Conclusions. Spectral characteristics of alcohol extracts from leaves of Punica granatum were studied, indicating the dominance of apigenin. A method of standardization of Punica granatum leaves on the quantitative content of flavonoids in terms of apigenin is proposed

The purpose of the work: development of criteria for the authenticity of raw materials and the quantitative determination of the amount of saponins in Gynostemma pentaphyllum herb.

Material and methods. The object of study was G. pentaphyllum (Thunb.) Makino herb harvested in the flowering phase from 2017 to 2020 on the territory of the Republic of Bashkortostan from a cultivated species. The determination of the authenticity of raw materials and the quantitative content of the amount of triterpene saponins in G. pentaphyllum was carried out by the spectrophotometric method based on the reaction with sulfuric acid.

Results. The criterion for the authenticity of saponins in Gynostemma pentaphyllum is a qualitative reaction with concentrated sulfuric acid followed by measurement of the UV spectra of the obtained complexes. The development of the quantitative determination of the amount of saponins was carried out by selecting the optimal extraction conditions: the type of extractant, the ratio of the weight of the raw material and the volume of the extractant, the extraction time, the degree of grinding of the raw material and the reaction time with concentrated sulfuric acid. In accordance with the selected conditions, the amount of saponins in G. pentaphyllum herb averages 17.24±0.07%.

Conclusions. Authenticity criteria and a method for quantifying the amount of saponins in raw materials in terms of β-escin, which is easily reproducible, accessible and not time-consuming, have been developed. The technique allows to evaluate the quality of Gynostemma pentaphyllum herb by the content of one of the groups of the main bioactive compounds – saponins.

Pyrazole derivatives are widely used as anticoagulants, antitumor, psychotropic and anti-inflammatory agents. Among the thietane-containing pyrazoles, we have found compounds promising for further in-depth studies as antidepressants, one of which is 3-bromo-1-(1,1-dioxothiethane-3-yl)-4-nitro-N-phenyl-1H-pyrazole-5-amine (I).

The objective of the work is to study the physical, physicochemical properties and spectral characteristics of the promising 3-bromo-1-(1,1-dioxothiethane-3-yl)-4-nitro-N-phenyl-1H-pyrazole-5-amine substance for the development of methods for determining identification.

Material and methods. The object of the study was 3 experimental batches of 3-bromo-1-(1,1-dioxothiethane-3-yl)-4-nitro-N-phenyl-1H-pyrazole-5-amine (I). The solubility of the chemical compound was determined in water and various organic solvents. IR spectra were recorded on the Infralum FT-02 spectrophotometer, UV spectra were recorded on the Shimadzu UV-1800. To determine identification, a reaction with a 20% sodium hydroxide solution was carried out. The melting point was measured by the capillary method on the "SMP 30" device. Thin-layer chromatography was performed on "Sorbfil" PTSH-AF-A-UV plates. Chromato-mass spectra were recorded on a gas-liquid chromatograph with an Agilent MSD 5977B quadrupole mass-selective detector.

The main results. Methods for determining the identification of a promising biologically active substance of 3-bromo-1-(1,1-dioxothiethane-3-yl)-4-nitro-N-phenyl-1H-pyrazole-5-amine (I) have been studied for the first time. It was found that the substance is a reddish-brown crystalline powder, easily soluble in acetone and dimethylformamide, and practically insoluble in water and alcohol. The melting point of substance I is from 182.6 to 184.0 °C. The analysis of substance I by IR spectroscopy made it possible to identify the absorption bands belonging to the pyrazole and substituents. Two peaks at 457.17 nm and 277.50 nm and one absorption minimum at 364.78 nm are recorded in the UV spectrum. Thin-layer chromatography and gas chromatography with mass spectrometric detection are proposed to confirm identification. As a result of the reaction with a 10% sodium hydroxide solution, a bright red staining is formed.

Conclusions. Based on the results of the study of the physical, physicochemical properties and spectral characteristics of 3-bromo-1-(1,1-dioxothiethane-3-yl)-4-nitro-N-phenyl-1H-pyrazole-5-amine, methods for determining identification are proposed.

The aim is to study the effect of extracts of Thymus marschallianus Willd. and Thymus serpyllum L. on the antidepressant activity of mice in the Porsolt test.

Material and methods. The evaluation of the antidepressant activity of animals was carried out using the Porsolt test on the 1st, 8th, 15th and 21st days of the experiment. The mice were divided into 6 groups – a control group and five experimental ones (6 animals in each group) receiving intragastric amitriptyline (10 mg/kg), alcoholic extract of Thymus serpyllum, water extract of Thymus serpyllum, alcoholic extract of Thymus marschallianus, water extract of Thymus marschallianus (the concentration of the thick extract was 100 mg/kg) during 21 days of the experiment. The control group received drinking water in an equivalent amount.

Results. Alcoholic and water extracts of Thymus marschallianus and Thymus serpyllum at a dose of 100 mg/kg did not show a statistically significant increase in the time of active swimming or a decrease in immobilization during the 21 days of the experiment compared to the group of control mice. On the 15th and 21st days of the study, the immobilization time in the experimental groups was statistically significantly higher compared to the group of animals treated with amitriptyline (10 mg/kg).

Conclusion. Alcoholic and water extracts of Thymus marschallianus and Thymus serpyllum at a dose of 100 mg/kg showed no antidepressant activity during the 21-day experiment.

In accordance with the approved concept of Russia's technological development for the period up to 2030, in order to achieve the goals of high-tech sectors of the economy, a sufficient number of highly qualified specialists is required. Given that the production of medicines was attributed to the main areas of technological sovereignty, the provision of domestic pharmaceutical enterprises with personnel becomes one of the most important state tasks.

The objective of the study is to analyze the current situation in the Russian pharmaceutical labor market in the manufacturing segment and to determine further prospects for its development for the staffing of domestic enterprises involved in the production of medicines.

Material and methods include recruiting agency reports data, up-to-date announcements for open vacancies of pharmaceutical companies and active pharmaceutical ingredients. Data from websites for applicants on the number of state-funded places in higher educational institutions in the fields of chemical technology and biotechnology. In the course of the work, such methods of analysis as generalization, methods of logical, systemic and comparative analysis were used.

Results and discussion. According to the study, there is a shortage of specialists at the enterprises manufacturing medicines in a number of federal districts of the Russian Federation. An analysis of the distribution of vacancies opened at pharmaceutical enterprises was made, as a result of which a shortage of personnel was revealed in a number of structural divisions, such as the production and commercial departments, as well as the design and development department. The educational programs implemented in a number of Russian universities aimed at training specialists in the field of pharmaceutical production technology were studied, and the need to expand the number of existing budget programs in order to fully meet the needs of the industry in highly qualified personnel was identified.

Conclusion. There is a clear shortage of competent personnel in the domestic pharmaceutical labor market, as evidenced by the large number of open vacancies throughout Russia. The distribution of vacancies by industrial departments allows us to conclude that pharmaceutical enterprises focus on not only the production of medicines, but also on innovative development, their commercial promotion, and the formation of an individual pharmaceutical brand. Specialized universities that train professionals in the field are able to provide the industry with only 45% of personnel, which indicates the need to increase state-funded training places in order to maintain and further increase the momentum of development of the Russian pharmaceutical industry.

In the structure of nosological forms of occupational diseases of drivers, the pathology of the musculoskeletal system amounts to 44%.

The purpose of this study is to assess the state of the musculoskeletal system of drivers using the method of clinical gait analysis, to analyze its spatiotemporal characteristics of gait.

Material and methods. 46 male volunteers were examined, average age 39.6±4.7 years, average weight 77.4±3.7 kg. 24 people were professional drivers with more than 8 years of experience and 22 people (comparison group) who were not professional drivers. The spatiotemporal and kinematic characteristics of the gait were recorded using the Vicon 3D video motion capture system (Vicon, Great Britain), the spatiotemporal parameters of the gait were analyzed using the Vicon Nexus and Vicon Polygon (Vicon, Great Britain) software.

Results. In the group of drivers, a significant increase in cadence, an increase in the time of double support, a decrease in the stride length and half step, a decrease in the stride time, and a decrease in gait speed were revealed.

Objective. To obtain new data on anthropometric indicators of boys and girls at the age of 13-18 years, permanently residing in the Orenburg region.

Material and methods. The study was conducted on 112 physically healthy adolescents permanently residing in the Orenburg region using routine anthropometric tools. The study included measuring the total, diametrical and girth dimensions of the torso and limb segments, the thickness of skin folds and body composition of the participants, as well as the strength index by carpal dynamometry.

Results. There was no obvious difference in the average growth rates, girth and diametrical dimensions in the respective age groups.

Conclusions. Smoothing of the border between the level of physical development of children of adolescent and youth groups was noted.

Recently, one of the topical issues of medicine is the problem of pelvic floor dysfunction. The most frequent manifestations of it include urinary incontinence, fecal incontinence, pelvic organ prolapse. The prevalence of urinary and fecal incontinence in old age reaches 50%, and more than 7% need urgent surgical correction of these conditions. Morphological studies of human fetuses allow us to trace in detail the features of the antenatal development of the pelvic floor for a better understanding of the anatomy and pathogenesis of myofascial insufficiency of the supporting apparatus of the pelvic organs.
The aim is to study the topography features of levator ani muscle in the intermediate fetal period of human development.

Material and methods. On fixed human fetuses of 14 to 26 weeks of gestation, morphometry of iliococcygeal part of levator ani muscle insertion to orienteers of chondropelvis was performed.

Results. The study revealed a physiological lowering (descension) of the tendinous arch of levator ani muscle. The process of descension is more pronounced in male fetuses due to more intensive longitudinal growth of pelvic bones; in female fetuses, the process of descension stabilizes at 21 weeks of intrauterine development.

Conclusion. The data obtained demonstrate the sexual features of the intrauterine development of the human pelvic floor in second trimester of gestation and can be used for the treatment of pelvic dysfunctions, taking into account the features of the topography of the tendinous arch of levator ani muscle.

The objective of the study was to determine the density of the lens in age-related cataract based on a spectrofluorimetric study and to identify the correlations of this indicator with the total time of ultrasonic exposure during phacoemulsification.

Material and methods. On the base of Krasnoyarsk Regional Ophthalmological Clinical Hospital named after Professor P. G. Makarov, the registration of the spectrofluorimetric index of lens density in 60 patients (60 eyes) was carried out, followed by cataract phacoemulsification and registration of the time of ultrasonic exposure.

Results. A high positive correlation of the lens density index with the total time of ultrasonic exposure used in cataract phacoemulsification was obtained (Pearson correlation coefficient = 0,86, р≤ 0,05). The complications of surgical treatment of highdensity cataracts that required anterior vitrectomy, implantation of rigid intraocular lenses, as well as anti-inflammatory treatment in the postoperative period are shown.

Conclusion. The spectrofluorimetric method for studying the density of the lens makes it possible to identify risk groups in cataract surgery based on the total ultrasound time.

The purpose of the study is to identify the most accurate and effective method for determining the curvature of the articular surfaces of the articular bones of the knee joint.

Material and methods. The material was 20 knee joints of amputated limbs of elderly and senile persons without injuries or diseases of the musculoskeletal system. Two methods for determining the curvature of articular surfaces were compared: using a patented device (patent No. 2011153311/13, 2011.12.27, Pavlovskaya E.A., Slesarenko N.A. Vlasenko A.N.) [1] and using a radius template (GOST 4126-82).

Results. Numerical values of the radii of curvature of identical sections of the articular surface of the medial femoral condyle were obtained using two methods. However, no significant difference was found between the compared methods for determining curvature.

Conclusions. The least labor-intensive and less expensive method for determining the curvature of the articular surface is the radius template measurement method.

The objective is to study the effect of the mechanical properties of the suture material on the poststernotomic complications in the ligature osteosynthesis of the sternum in cardiac surgery practice.

Material and methods. In the period from 2008 to 2022, during heart operations under cardiopulmonary bypass, the longitudinally dissected sternum in the 1st group of patients (n= 1487) was sutured traditionally with 7-8 interrupted stitches using steel wire, the modulus of elasticity of which is much higher than that for the bone. In the 2nd group (n=758) sternum was sutured with a continuous suture with two nylon threads of polyamide nature, having a modulus of elasticity close to that of the bone. Each of them made 3-5 stitches.

Results. In the steel wire osteosynthesis group, 34 (2.3%) cases of sternal instability were observed, including 16 (1.1%) cases with the addition of deep sternal infection (DSI). After osteosynthesis of the sternum with a nylon thread with a continuous suture technique, there were no cases of instability of the sternum; 1 (0,1%) сase of DSI was observed.

Conclusion. The results of the study indicate the positive effect of the mechanical properties of the suture material on the bone tissue in the prevention of poststernotomic complications during ligature osteosynthesis of the sternum.