The article presents the results of a retrospective analysis of the incidence of hemorrhagic fever with renal syndrome (HFRS) in the Republic of Bashkortostan for 2010-2016. Among the sick, men of working age predominated (75.2%). In the age groups over 50, the incidence rate among women is increasing. In the age group of 60 years and older, the ratio of the number of sick men and women is 1: 1. Against the background of traditional seasonal changes, the incidence of HFRS increased by 1.9 times in December,3.1 times in January, and 4.1 times in February. An increase of infection contamination on the territory of households was revealed (in 38.6% of cases).72.6% of men and 54.6% of women applied for medical care during the first five days after the onset of the disease. Later thanfive days after the onset of the disease, 32.4% of men and 42.6% of women were hospitalized. Among women, heavy forms of HFRS were established 1.8 times more often than in men.

In this article authors team explored medical and social aspects in patients newly diagnosed with tuberculosis in the late stages of HIV-infection. For this purpose, we examined 101 patients with newly diagnosed pulmonary tuberculosis combined with HIV- infection. Two groups were formed: the first group - 60 patients with high adherence to treatment (courses of TB (PTT), antiretroviral therapy (ART), in the presence of toxic and allergic reactions - plasmapheresis (PA) in the development of severe destructive forms of tuberculosis with massive smear and inefficient course of the intensive phase of PTT-intravenous laser irradiation of blood (VLOK); the second group - 41 patients with low adherence to treatment (only PTT and ART were performed, patients refused PA and VLOK). The results revealed the most significant social factors affecting adherence to treatment in patients with co-infection (TB / HIV), also showed their effect on the effectiveness of the anti-TB and antiretroviral therapy. Based on these results the following conclusions have been made: 1. The social conditions (residence, the presence of living space, families and children, the nature of household contacts, type of education, employment, criminal record and antisocial habits) affect adherence to antiretroviral and anti-TB treatment in TB patients with advanced HIV-infection. 2. In socially adapted patients with stable high motivation and commitment to treatment in the presence of new-onset tuberculosis in the late stages of HIV-infection, it is possible to achieve clinical efficacy, positive X-ray laboratory dynamics and relief of adverse events. 3. Adverse social factors, causing maladjustment of the individual in society, reduce motivation and commitment to treatment, contribute to the low efficiency of anti-TB and antiretroviral therapy in patients with co-infection (TB / HIV) and impair the vital prognosis.

State of health of 4485 primary school children in the cities Ufa, Salavat and Ishimbai has been comparatively assessed and analyzed on the basis of physical fitness and distribution by health groups. It is established that the lowest values are found both in boys and girls in Ishimbai. But the most unfavorable picture was in the city of Ufa, showing the smallest proportion of children with harmonious development and children with first group of health, and 28,37% of schoolchildren has the third group of health. The first place, both in the structure of morbidity and in the prevalence of diseases among children of primary school age, is occupied by respiratory diseases. Second and third places are held by diseases of the musculoskeletal system, diseases of the endocrine system, eating metabolic disorders, only in the city of Salavat the diseases of the eye came third. It is noted that most children have an increased risk of developing diseases associated with the conditions and way of life of the child.

The key stage during complex rehabilitation of ostomy patients is restorative surgery, but there are still no definite criteria on determining the period for restorative operation.The aim is to identify the role of intraluminal ultrasonography with dopplerography in estimation of changes happening in the intestine of patients with stomas, in order to determine terms and indications for the restorative operation.The paper presents the results of intraluminal ultrasonography with dopplerography in 79 patients with stomas who underwent radical surgery for cancer of the left colon complicated with an acute intestinal obstruction.Introduction of the method of intraluminal ultrasound dopplerography has enabled to determine criteria and terms for restorativeoperations beginning from the 4th week under achievement of blood peak flow in the wall of 10,45±0,92 cm/s and thickness of the wall of adducting intestine 0,18±0,02 cm.

The steady increase in the incidence of colorectal cancer and other diseases of the colon leads to the rise in the number of operations ending with ostomy. The study analyzes the causes of late stomy complications in 141 patients. 44 (31.2%) of them hadparastomal hernias, 29 (20.6%) prolapse, and 9 (6.4%) patients had a stricture. New methods of surgical correction of complicated stomas have been implemented into practice. Results of these surgical reconstructions were evaluated in the study. Reconstructive procedures for complicated stomas, made in the amount of movement of the stoma to a new location with retroperitoneal transportation, allows to obtain satisfactory results, significantly improve the quality of life with the possibility of using modern care for the ostomy, enabling proper social adaptation of the patient. Development of new methods of surgical correction of stoma complications allows to improve the results of reconstructive operations on the stoma and requires further development of this direction in the framework of the program of surgical rehabilitation of stomy patients.

Unformed duodenal and high intestinal fistulas represent a major problem in abdominal surgery. Surgical interventions in these patients are mainly carried out urgently because large losses of intestinal content through fistulae lead to the weakening and exhaustion of patients.The article presents long-term experience of surgical treatment of patients with duodenal and high unformed intestinal fistulas using the original integrated approach in the main group of patients. Local application of collagen against selective introduction of angioprotectors enabled to reduce the frequency of intestinal sutures insolvency after fistula closure, and in cases of its occurrence, it was mostly partial. Thus, the developed technique made it possible to reduce the frequency of insolvency of intestinal sutures, the number of newly formed intestinal fistulas and purulent-septic complications.

The article is devoted to the study of remote results of eradication therapy of Helicobacter Pylori and quality of life in patients suffering from gastric ulcer and duodenal ulcer during five-years follow-up in an outpatient settings. We conducted a comprehensive survey of 233 people with gastric and duodenal ulcers aged from 18 to 60. The first group included 183 patients with peptic ulcer disease, including 31 patients with gastric ulcer and 152 patients with peptic ulcer of the duodenum, which were under regular medical check-up at the polyclinic and were trained in "gastro-school". The second group consisted of 50 patients with peptic ulcer disease (13 patients with gastric ulcer, 37 patients with peptic ulcer of the duodenum), which for one reason or another did not fulfill the recommendations of the therapist and were not trained in "gastro-school". The groups were matched for age, sex and severity of changes in the gastroduodenal system. According to the results of long-term dispensary observation of patients with peptic ulcer disease in the outpatient conditions in compliance with the principles of eradication therapy by a comprehensive examination it was established that successful eradication, a dynamic clinical supervision, training in "gastro-school" significantly improve the patient's quality of life, ability to work, the morphological condition of the gastric mucosa and reduce the frequency of relapses.

Indicators of local immunity of a nasal mucous membrane at 47 infants born prematurely on the term of a gestation of 28-37 weeks have been studied. Determination of level of antibodies (IgA, IgG, IgE) and cytokines (TNF-α, IL-1β, IF-γ) in swabs from the mucous membrane was carried out by method of the immunofermental analysis taking into account the level of the protein. It is established that prematurely born children have transient deficiency of IgG at the age of 6 months (2,08 (0,78-6,99) mg/ml), low levels of IgE at the age of 12 months (0,89 (0,47-1,32) ng/ml), low levels of IF-γ at the age of 6 (7,51 (4,84-13,82) pg/ml) and 12 months (8,28 (4,70-12,07) pg/ml) and hyperproduction of pro-inflammatory cytokine IL-1β during the first year of life. The failure of the antibody and interferon protection is most expressed at very prematurely born children. Indicators of mucosal immunity of the nasal cavity can be used for pathogenetic approaches to prevention and treatment of infectious and inflammatory diseases of respiratory system at prematurely born children.

Today one of the urgent problems of adolescent gynecology is dysmenorrhea. The paper presents the results of a complex treatment of primary dysmenorrhea in 106 girls aged 15-17, depending on the severity of the disease and vegetative state of patients.In patients with predominance of combined and parasympathetic type of the autonomic nervous system with no deviations of hormonal status administration of nonsteroidal anti-inflammatory drugs was very effective. In case of moderate dysmenorrhea, accompanied by sympathetic tone of autonomic nervous system and luteal phase defect, the use of gestagens in the second phase of the cycle was accompanied by a stable therapeutic effect and relief of pain from 93,3% of girls by 6 months of therapy. Administration of the combined oral contraceptives in severe dysmenorrhea with excessive estradiol levels and parasympathetic tone of the autonomic nervous system contributes to the normalization of menstrual function and hormonal status in 90,0% of patients.Timely conducted comprehensive treatment measures based on identified pathological processes, vegetative state and psychoemotional peculiarities improve the quality of life of adolescents and prevent violations of the formation of the reproductive system.

Chronic rhinosinusitis (CRC) is one of the most common human diseases. The bacterial spectrum is more often represented by microbial associations of non-spore-forming anaerobic, aerobic bacteria and fungi. Perhaps, destroying some bacteria, treatment can lead to uncontrolled growth of other more dangerous microorganisms. It is difficult to foresee the result of their interaction and effects on human’s health when antibacterial drugs are introduced. Therefore, it is necessary to focus on the local sensitivity of microorganisms to chemical agents. We analyzed bacteriological studies of nasal cavity smears of patients with chronic rhinosinusitis (n =478) from ENT Department of the Republican Clinical Hospital n.a.G.G. Kuvatov. The features of microbial landscape in patients with CRC were studied, sensitivity and resistance to the most commonly used antibiotics and antifungal agents was determined. Our study showed that in bacteriological studies the gram-positive flora was most often seen from the nasal cavity of CRC, which was highly sensitive to ceftriaxone, ertapenem and rifampicin, and is resistant to protected penicillins. In 4% of cases there were fungi resistant to antimycotic drugs, which increased compared with 2014.

The objectives of the study were to analyze the frequency of malapposition and stent coverage in patients with chronic total occlusion (CTO) lesions and non-CTO lesions after drug-eluting stent (DES) implantation by optical coherence tomography (OCT). In total 64 patients with 68 lesions targeted for coronary revascularization were enrolled in the study. All of the patients underwent OCT imaging immediate after stenting and 6 months after it. Examination was conducted using OCT device in frequency field (C7- XR OCT Intravascular Imaging System, St. Jude Medical, St. Paul, Minnesota). Patients were divided into 3 groups: first group - patients with CTO, second group - lipid rich plaques without CTO, third group - non-lipid rich plaques without CTO. LRP was de-fined as the plaque with lipid content in 2 quadrants. Non-LRP consisted of fibrous, fibrocalcific plaque, and lipid plaque with less than 2 quadrants lipid content.Malapposition, tissue protrusion, and intrastent thrombus were more frequent in the CTO and LRP groups. At 6-month followup, malapposition and cross sections with uncovered struts were most frequently observed in the CTO group. Although the incidence of stent thrombosis was non-significantly higher in the CTO group than the other two groups, no events were observed in patients with CTO.Thus, patients with CTO lesions showed unfavorable responses to DES in the acute phase as well as at the 6-month follow-up, indicating the link between the lesion morphology and artery healing process.Key words: chronic total occlusion, optical coherence tomography, stents.

Recently the frequency of surgeries in cases of coronary heart disease has significantly increased. Yearly more than 7 million of percutaneous coronary interventions are carried out worldwide. The general lethal outcomes after such interventions make up 0.4-1.9%.The study aimed to analyze the correlation between indicators of ultrasound examinations and complications in percutaneouscoronary intervention in patients with coronary heart disease. The study included 2610 patients with coronary heart disease of functional class 2, who underwent stenting of the coronary arteries in a planned manner between 2003 and 2015 in the Republican cardiological centre. Analysis of the data showed that the most significant predictors are: ejection fraction, end diastolic volume, aortic diameter, end-systolic size of the left ventricle. The study also revealed correlations between the risk of development of intraoperative complications and indicators of echocardiography.

Knee joint (KJ) menisci injuries in children remains one of the topical problems of pediatric surgery and traumatology. Despite of the large number of clinical symptoms of menisci damage, their diagnosis is still complicated.The research aimed to study the features of clinical picture of menisci injuries in children.The study included 272 child with KJ menisci injuries. To study the clinical manifestations of menisci injuries, depending on the age of the child, the patients were divided into 2 groups. The 1st group included 132 children aged 7 to 12. The 2nd group consisted of 140 patients aged 13 to 17. Comparative analysis revealed age characteristics of clinical manifestations of menisci injuries. In young children joint pathology is accompanied by vague and slight symptoms. Children of the second group showed severe pain syndrome, restrict activity and frequent locked joint.

The article deals with one of the actual problems of paediatrics - arterial hypertension. Despite the high prevalence of the disease, the pathogenesis of hypertension is very complex and involves many aspects that require further study. At present, the inverse relationship between the concentration of vitamin D and the activity of the renin-angiotensin-aldosterone system (RAAS) has been proved.The aim of the study is to identify the relationship between the level of vitamin D, renin and body mass index in adolescents with primary arterial hypertension.The study included 87 adolescents aged 12-17 years. Patients were divided into 2 groups depending on BMI. The first group included 31 adolescents with overweight and obesity, average BMI (28.2±0.8 kg / m²). The second group consisted of 56 adolescentswith normal BMI, average BMI (21.7±1.6 kg / m²).The degree of severity of vitamin D deficiency in children with primary hypertension and overweight (15.0±1.0 ng / ml) is greater than in children with hypertension and normal body weight (18.1±1.1ng / ml) p = 0.03.The level of renin in the first group with increased BMI (66.5±6.3 pg / ml) is more pronounced than in children of the second group with normal BMI(57.1±4.9 pg / ml) p = 0.04.So, the presence of inverse relationship between the vitamin D content and plasma renin activity in patients with hypertensionhas been proven, as well as the more pronounced prevalence of vitamin D deficiency in obese patients.

The article presents the results of studying the production of serum cytokines in patients with tick-borne borreliosis (ICB). During eruptive phase of the disease the level of serum anti-inflammatory cytokines (TNF-α, IL-6, IL-8, IL-18) significantly increases In the dynamics of the disease, the blood concentration of TNF-α is significantly reduced, however, by the recovery period normalization of the average values of TNF-α does not occur. IL-6 content in the serum by the period of the reverse development of symptoms significantly increases, but in the period of early convalescence it decreases almost by half, and reaches the values of the control group by three months after discharge. In the dynamics of the disease, the concentration in the blood of IL-8 decreases. At the same time, the trend towards normalization of IL-8 was observed in both groups, but at medium severity it was more pronounced. The content of anti-inflammatory cytokine (IL-10) gradually rises and reaches its peak to the period of the reverse development of symptoms, then decreases slowly and remains statistically significantly high after 3 months and reaches the norm after 6 months of dispensary observation.

Currently, researchers are considering the genesis of non-viable pregnancy from multifactorial positions: clinical, endocrinological, immunological, cytogenetic, morphological, infectious. The modern concept of treatment of this disease requires timely complete rehabilitation of women, aimed at the restoration of morpho-functional state of the endometrium after emptying the uterus, correction of immunological disorders with the aim of pregravid preparation in the future.The aim of our study was to evaluate the immune status of women with non-viable pregnancy and the rationale for the use of immunomodulator Derinat in a complex rehabilitation of women after drug-induced abortion of non-viable pregnancy.Rehabilitation of patients after medical abortion with the inclusion in the regimen of the drug Derinat improves the efficiency of traditional complex treatment and rehabilitation pathogenetically reasonable impact on the immunological status and regenerative-plastic disorders of the endometrium in patients with non-vital pregnancy.The results of pilel biopsies demonstrate the full transformation of the endometrium and restoration of glands per unit area of biopsy in the group of women who received timely treatment with Derinat in the first menstrual cycle after drug-induced abortion of non-viable pregnancy.

Bladder cancer is one of the most common malignancies and contributes significantly to the overall human cancer burden. In order to solve the difficulties in the highly sensitive detection bladder cancer, detecting tumor residual and defining the margin of bladder tumor we use intraoperative fluorescence molecular imaging.The study was to synthesize a targeting agent indocyanine green-arginine-glycine-aspartic acid which is integrin αvβ3-targeted,fast clearing near-infrared probes both in vitro and in vivo for bladder cancer Imaging-guided therapy. This targeted agent could be used for fast clearing hydrophilic near-infrared dye indocyanine green for detecting αvβ3 receptor expressing tumor foci during operation and finishing imaging guided surgery, using preclinical in vivo mouse models. The indocyanine green was conjugated with the arginine-glycine-aspartic acid, the indocyanine green-arginine-glycine-aspartic acid was synthesized. The toxicity of indocyanine green-arginine-glycine-aspartic acid was measured by MTT assay.The probes specificity was assessed in vitro and in vivo using the MB49 (αvβ3 receptor high expressing) bladder cancer celllines in mice models. Fast clearing Near-infrared probes conjugated with arginine-glycine-aspartic acid peptide targeting αvβ3 receptor can be used for highly specific and sensitive detection of tumor lesions in vivo.These preclinical findings with intraoperative optical imaging technique holds promise to offer more sensitive and accuratebladder cancer resection guidance and achieve better surgical outcomes in cancer patients.

Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies showed that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC, and a potentially novel diagnostic and therapeutic target for OC treatment.

In recent years hyaluronan-based injectable and cosmetological products have been widely used. The spectrum of investigation of biological functions and mechanisms of action of hyaluronan and its fragments is widening, but existing evidence about their pharmacological properties refer mainly to visualized clinical results.The study aimed to evaluate histological changes of tissue of skin at experimental animals during intradermal injection of nativehigh-molecular hyaluronan. It was intradermally injected by mesotherapy technique to females of mature rats. It is shown by histological methods of skin research in the area of injection (coloring by a hematoxylin and eosine, according to Van-Gizona, Mallori, Hale and a silver impregnation according to Foote) that in the first days we can observe not expressed inflammatory tissue reaction with edema and diffuse infiltration by cellular elements, mainly macrophages. The next days (the 7th, 21st days) showed proliferation of fibroblastic cells, increase of biosynthesis of collagen and glycosaminoglycan.

The maintenance of phenotypic heterogeneity in the cell population is a mechanism of evolutionary conservatism, which is a mechanism for population survival stress exposure. The researchers found that the genome of the cancer cell subpopulation survived the next one when using other lethal drugs (DTPS) and showed a suppressed chromatin state characterized by histone H3 lysine 9 and 27 (H3K9 and H3K27) increasing degree of methylation.

Blepharokeratoconjunctivitis (BKC) refers to a series of conjunctival and corneal disease secondary to blepharitis. Intense pulsed light (IPL) devices contain high-intensity light sources, which emit polychromatic light from 515 nm to 1200 nm. We report the effect of IPL in three cases of BKC.The first case presented eyelid congestion; crusting and scaling at the eyelash root; meibomian gland obstruction and conjuncti-val hyperemia in both eyes. The left eye presented old central corneal scarring with neovascularization. BKC was diagnosed. The male patient was treated with three times of IPL and traditional treatment. The second case presented scaling and sleeve-form crusting at the eyelash root; meibomian gland arranged irregularly with opening obstruction; marked conjunctival hyperemia in both eyes. The left eye presented opacities with much neovascularization. In vivo confocal microscopy and optical microscopy examination of eyelid lash showed there were lots of Demodex folliculorum mites in the eyelash follicles. Demodex folliculorum mitesin festation and BKC were diagnosed. The female patient was treated with once of IPL and traditional treatment. The third case presented eyelid congestion; meibomian gland pouting and capping; conjunctival hyperemia and marginal infiltrates of cornea with pannus formation in both eyes. BKC was diagnosed. The female patient was treated with twice of IPL and traditional treatment.The first case recovered within 17 days. The second case recovered within 23 days. The third case recovered within 14 days. And their ocular surfaces were stable at 1-month follow-up.Compared with topical medicine treatment of BKC requiring at least 1 month, IPL treatment shortened the course of BKC.

Currently, most of the world’s countries are intensively suffering from major natural disasters, accidents, catastrophes leading to great material and human losses. The Kyrgyz Republic (KR) is a potentially dangerous region for the emergency situations (ES) of different nature. In modern conditions, in KR the role and responsibility of authorities are increasing in the field of safety provision and protection of environment from catastrophes’ consequences and preparation of region to ES. In the system of rendering assistance, medical and medicinal supplies are priority, which must be implemented on a single methodological basis, with unified principles. Based on logical and analytical analysis, international experience, scientific literature, using the systemic approach andexpert opinions of specialists, the principles of organization of medical and medicinal provision of victims in emergency situations in the Kyrgyz Republic, as well as the possibilities for their implementation are presented.

In the last decades the tendency to increased incidence of endometrial cancer has been noticed in most countries of the world. In most patients pathological endometrial processes develop against prior endocrine and metabolic disorders.Current medical literature covers only few cases of patients with giant ovarian tumors.The article presents the results of successful treatment of a patient suffering from endometrial cancer in combination with a giant ovarian tumor. Data on morbidity, diagnosis, and adequate treatment of this pathology are given in the paper.

Today, the prevalence of hepatobiliary system diseases among population has a tendency to continuous increase and is becoming a social disorder. The leading place among the pathologies of biliary system belongs to cholelithiasis, which can be diagnosed at the stage of crystallized concrements.The study presents data on the physical and mental aspects of life quality in patients with cholelithiasis. A total of 106 workingage patients after laparoscopic cholecystectomy were studied. To evaluate the effectiveness of accelerated physical rehabilitation patients were divided into two groups: I - primary (n = 79), with rehabilitation treatment in the sanatorium "Yumatovo" and II - comparison group (n = 27) was observed in the outpatient setting. After treatment, clinical improvement was noted, as well as restoration of free radical oxidation and improvement of quality of life. Analysis of the quality of life in physical and mental health revealed significantly higher values in patients of the I group, compared with the patients of the II group.

Due to progressive deterioration of the health status of youth, the problem of increasing the reserves of health and adaptive capabilities of the organism becomes especially important. Currently, girls are often diagnosed with anemia, caused by a decrease in the concentration of hemoglobin in the blood. The article deals with the relationship between the indicators of erythrocytes and the physical capabilities of the organism together with the emotional status of 258 female students of the university. The study determined the main indicators of erythrocytes, assessed physical endurance by the size of the cardiorespiratory index, physical performance in terms of the maximum consumption of oxygen and emotional state according to the results of the questionnaire. It was revealed that the level of physical endurance correlates with the hemoglobin content, the average volume of erythrocytes and their hemoglobin saturation. The change in these erythrocyte indices does not affect the physical capacity. The indicators of the emotional status of students correlate with physical endurance and work capacity.

The results of the conducted epidemiological research revealed the connection between urolithiasis and cardiovascular diseases, chronic kidney disease, diabetes and metabolic syndrome.Development, progressing and recurrence of urolithiasis depend on many reasons, one of which is the state of calcium ex-change, because it’s the main element, making up the calculus.The study aimed to reveal the risk factors for osteoporosis development and clinical manifestations of metabolic syndrome in patients with urolithiasis.The study included 44 patients with urolithiasis. Risk factors were assessed using questionnaire, clinical examination included waist circumference measurement, determination of BMI and daily calciuria.Risk factors for osteoporosis development were revealed in 20 (45.5%) of patients with urolithiasis. These risk factors prevailedin patients with BMI 25 kg/m2 and more (р=0,0937), as well as waist circumference being 80 cm and more (p=0.022).Thus, the results of analysis of osteoporosis risk factors, clinical manifestations of metabolic syndrome, indices of daily calciuria in patients with urolithiasis proved the existence of pathogenetic connection of osteoporosis, metabolic syndrome and urolithiasis.

Colorectal cancer (CRC) is a group of benign neoplasms of epithelial nature, located in the large bowel and anal canal. CRC is one of the commonest cancers, making up almost 10% of all diagnosed cases of benign epithelial tumors worldwide. The prevalence of CRC in different geographical areas varies a lot. The highest morbidity has been revealed in the USA, Australia and Western Europe.Over the last 10-15 years the treatment of patients with liver metastases has significantly changed due to the progress in surgical treatment of metastatic lesions of the liver and the emergence of new drugs. The most promising direction in the treatment of synchronous intrahepatic metastases is a surgery, which is carried out simultaneously with removal of the primary tumor and metastases in the liver.Further investigations of CRC with isolated metastases are required. It will increase clinical efficacy and safety of treatment.

Cervical cancer ranks first among oncological diseases of female reproductive system. Most studies of the last decade are devoted to the problem of early diagnosis and prediction of tumor process. One of the promising biomarkers of tumor progression are long non-coding RNAs, known as key regulators of the majority of intracellular processes. This review considers the perspective of searching new long non-coding RNAs and the use of their potential in diagnosis of oncological diseases in general and cervical cancer in particular.

The article presents an overview of Russian and foreign literature on diagnosis, selection of a method for treatment of purulentseptic complications in HIV infection and AIDS. Clinical manifestations of suppurative complications in HIV infection are poorly expressed, atypical and often do not correspond to the severity of the complication, and the revealed changes with additional methods of investigation. It is noted that it is expedient to conduct radiation research methods to detect purulent complications. Important are the laboratory methods of blood testing, characterized by leukopenia (especially leukocytopenia), anemia, thrombocytopenia, aggravating moments are opportunistic infections and comorbid pathology. Leukopenia, thrombocytopenia are also prognostic factors of mortality. In the diagnosis of purulent processes, the leading methods are computed tomography, especially multispiral, magnetic resonance imaging. These methods are characterized by high sensitivity and specificity (90-95%), allow to identify small abscesses (<10 mm), to accurately establish localization, including in 3D measurement and, accordingly, to choose rational and safe methods of puncture and drainage. Questions of surgical tactics in the abscesses of the thoracic and abdominal cavities, retroperitoneal space are discussed in the article.

Тhe problem of rosacea prevalence and treatment has increased over the last few decades. Currently, it is believed that the leading role in the disease development is given to angioedema with the primary lesion of the face vessels as the manifestation of vegetative dystonia. According to the available literature data the rosacea therapy effectiveness depends on the duration of the process, the severity of the disease and the concomitant pathology. Systemic rosacea therapy includes prescription of antibacterial drugs and retinoids.

Infections associated with health care (IAHC) or nosocomial infection (NI) (Healthcare associated infections - HAIS) are infections acquired by patients during treatment and medical care. Surgical site infections (SSI), according to WHO are the most frequent type of nosocomial infection in countries with middle income. SSI is found in 1/3 of patients after surgical intervention. The review provides data about the epidemiology and prevalence of SSO and describes methods of preoperative prevention.

Organs transplantation is a method of choice in the treatment of many acute and chronic diseases in their final stage, as well as in some cases of primary malignant neoplasms. With the increase in the number of operations performed, data on a variety of complications of these interventions, including neurological ones, began to accumulate.Patients, who underwent transplantation of internal organs, are forced to be on immunosuppressive therapy. It includes the appointment of glucocorticoids (prednisolone or methylprednisolone), inhibitors of calcineurin (cyclosporine A or tacrolimus), inhibitors of inosine monophosphate dehydrogenase (mycophenolate mofetil or mycophenolic acid). The severity of neurological disorders can range from mild (headache, dizziness, paresthesia, dysesthesia, tremor, sleep disturbance, photophobia) to extremely severe manifestations (mental confusion, seizures, cortical blindness, encephalopathy and coma). Typically, these symptoms occur soon after transplantation. Most likely, the neurotoxic effect of drugs develops against the background of intensive therapy with immunosuppressants and has a significant impact on the survival and life quality of patients.